Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia.
Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia.
复制标题
精神分裂症黑质的质子磁共振波谱。
DOI：
10.1016/j.schres.2013.04.036
复制
发表时间：
2013
影响因子：
4.5
通讯作者：
Lahti,AdrienneC
中科院分区：
文献类型：
--
作者：
Reid,MeredithA;Kraguljac,NinaV;Avsar,KathyB;White,DavidM;denHollander,JanA;Lahti,AdrienneC
研究背景精神分裂症的证据表明，在精神分裂症的病理生理学中，多巴胺和谷氨酸神经递质系统受到破坏。多巴胺在黑质中产生，但很少有神经影像学研究专门针对这一结构。事实上，还没有使用质子磁共振波谱（MRS）对精神分裂症患者的黑质进行研究。我们试图证明在3 T从黑质获取单体素MRS测量的可行性，并确定哪些代谢物可以可靠地量化在精神分裂症患者和健康controls. METHODS我们使用了涡轮自旋回波序列与磁化传递对比可视化黑质和单体素质子MRS量化水平的N-乙酰天冬氨酸，谷氨酸和谷氨酰胺（Glx），对35例精神分裂症患者和22例健康对照者的左侧黑质和胆碱进行了光谱分析，并对两组的神经代谢物进行了定量。我们发现两组之间的N-乙酰天冬氨酸/肌酸、Glx/肌酸或胆碱/肌酸水平无差异。我们发现Glx/肌酸和整体认知性能之间的显着相关性，测量与可重复电池的神经心理状态评估（RBANS），在控制，但不是patients，差异是统计学显着的。CONCLUSIONSOUR的研究表明，从黑质精神分裂症获得单体素MRS数据的可行性。这种测量可能被证明是有用的，在了解生化基础的细胞功能，在一个地区牵连在精神分裂症的病理生理。
BACKGROUNDConverging evidence in schizophrenia points to disruption of the dopamine and glutamate neurotransmitter systems in the pathophysiology of the disorder. Dopamine is produced in the substantia nigra, but few neuroimaging studies have specifically targeted this structure. In fact, no studies of the substantia nigra in schizophrenia have used proton magnetic resonance spectroscopy (MRS). We sought to demonstrate the feasibility of acquiring single-voxel MRS measurements at 3T from the substantia nigra and to determine which metabolites could be reliably quantified in schizophrenia patients and healthy controls.METHODSWe used a turbo spin echo sequence with magnetization transfer contrast to visualize the substantia nigra and single-voxel proton MRS to quantify levels of N-acetylaspartate, glutamate and glutamine (Glx), and choline in the left substantia nigra of 35 people with schizophrenia and 22 healthy controls.RESULTSWe obtained spectra from the substantia nigra and quantified neurometabolites in both groups. We found no differences in levels of N-acetylaspartate/creatine, Glx/creatine, or choline/creatine between the groups. We found a significant correlation between Glx/creatine and overall cognitive performance, measured with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), in controls but not patients, a difference that was statistically significant.CONCLUSIONSOur study demonstrates the feasibility of obtaining single-voxel MRS data from the substantia nigra in schizophrenia. Such measurements may prove useful in understanding the biochemistry underlying cellular function in a region implicated in the pathophysiology of schizophrenia.