The Role of CARD9 in Metabolic Diseases
The Role of CARD9 in Metabolic Diseases
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CARD9 在代谢疾病中的作用
DOI：
10.1007/s11596-020-2166-4
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发表时间：
2020-04-01
影响因子：
2.4
通讯作者：
Xiang, Ming
中科院分区：
文献类型：
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作者：
Tian, Cheng;Tuo, Ya-li;Xiang, Ming
半胱天冬酶募集结构域蛋白9（CARD 9）是一种衔接蛋白，在模式识别受体（PRRs）介导的NF-κ B激活中起着关键作用。B和丝裂原活化蛋白激酶（MAPK）。这激发了促炎细胞因子的启动并导致炎症反应，这已被认为是慢性炎症的关键因素。目前研究表明，CARD 9与肥胖、胰岛素抵抗、动脉粥样硬化等代谢性疾病密切相关，本文就CARD 9信号通路及其在代谢性疾病中的作用进行综述。
Caspase recruitment domain containing protein 9 (CARD9) is an adaptor protein that plays a critical role in pattern recognition receptors (PRRs)-mediated activation of NF-?B and mitogen-activated protein kinase (MAPK). This elicits initiation of the pro-inflammatory cytokines and leads to inflammatory responses, which has been recognized as a critical contributor to chronic inflammation. Current researches demonstrate that CARD9 is strongly associated with metabolic diseases, such as obesity, insulin resistance, atherosclerosis and so on. In this review, we summarize CARD9 signaling pathway and the role of CARD9 in metabolic diseases.