Ultrasound stimulation inhibits recurrent seizures and improves behavioral outcome in an experimental model of mesial temporal lobe epilepsy
Ultrasound stimulation inhibits recurrent seizures and improves behavioral outcome in an experimental model of mesial temporal lobe epilepsy
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DOI：
10.1016/j.yebeh.2015.04.008
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发表时间：
2015-08-01
影响因子：
2.6
通讯作者：
Jeon, Daejong
中科院分区：
文献类型：
--
作者：
Hakimova, Hilola;Kim, Sangwoo;Jeon, Daejong
目前癫痫的治疗主要包括药物或侵入性手术。最近，超声（US）刺激已被认为是一种有前途的工具，用于非侵入性治疗脑疾病，包括癫痫。然而，在颞叶癫痫（TLE）中，一种常见的癫痫形式，超声刺激后的神经生理和功能结局尚未明确。为了解决这个问题，我们开发了一种经颅脉冲US刺激的范例，以有效地抑制在最初的急性期在红藻氨酸（KA）诱导的小鼠模型的近中TLE的癫痫发作活动。脉冲US刺激抑制急性癫痫发作活动，并且延迟！癫痫持续状态（SE）的发作或抑制。在初始阶段接受US刺激的红藻氨酸治疗的小鼠表现出更少的自发性复发性癫痫发作（SRS），并改善了评估癫痫慢性期社交和抑郁的行为任务的表现。我们的研究结果表明，在癫痫急性期的US刺激可以抑制SRS，并改善小鼠模型的menial TLE的行为结果。目前的研究表明，无创经颅脉冲超声刺激可能是可行的辅助治疗癫痫患者。这篇文章是题为“癫痫状态”的特刊的一部分。(C)2015 Elsevier Inc. All rights reserved.
Current therapies for epilepsy consist mostly of pharmacological agents or invasive surgery. Recently, ultrasound (US) stimulation has been considered a promising tool for the noninvasive treatment of brain diseases, including epilepsy. However, in temporal lobe epilepsy (TLE), a common form of epilepsy, neurophysiological and functional outcomes following US stimulation are not well defined. To address this we developed a paradigm of transcranial pulsed US stimulation to efficiently suppress seizure activity in the initial acute period in a kainate (KA)-inducecl mouse model of mesial TLE. Pulsed US stimulation inhibited acute seizure activity and either delayed! the onset of or suppressed status epilepticus (SE). Kainate-treated mice that had received US stimulation in the initial period exhibited fewer spontaneous recurrent seizures (SRSs) and improved performance in behavioral tasks assessing sociability and depression in the chronic period of epilepsy. Our results demonstrate that US stimulation in the acute period of epilepsy can inhibit SRSs and improve behavioral outcomes in a mouse model of menial TLE. The present study suggests that noninvasive transcranial pulsed US stimulation may be feasible as an adjuvant therapy in patients with epilepsy. This article is part of a Special Issue entitled "Status Epilepticus". (C) 2015 Elsevier Inc. All rights reserved.