History of allergies and autoimmune diseases and risk of brain tumors in adults
History of allergies and autoimmune diseases and risk of brain tumors in adults
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DOI：
10.1002/ijc.10320
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发表时间：
2002-05-10
影响因子：
6.4
通讯作者：
Inskip, PD
中科院分区：
文献类型：
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作者：
Brenner, AV;Linet, MS;Inskip, PD
为了探索免疫系统在脑肿瘤发展中的可能影响，我们在一项大型的以医院为基础的病例对照研究中评估了过敏史和自身免疫性疾病与脑肿瘤风险之间的关系。病例（n 782）是最近在波士顿、凤凰城和匹兹堡（美国）医院诊断为胶质瘤（n 489）、脑膜瘤（n = 197）或听神经瘤（n = 96）的患者。对照组（n = 799）为因各种非恶性疾病住院的患者，按医院、年龄、性别、种族/民族和居住地与医院的距离与病例频率匹配。研究护士通过对患者的个人访谈收集数据。使用无条件逻辑回归计算比值比（OR）和95%置信区间（CI）。胶质瘤与任何过敏史（OR = 0.67，95%CI = 0.52-0.86）或自身免疫性疾病史（OR = 0.49，95%CI = 0.35-0.69）呈显著负相关。脑膜瘤或听神经瘤与任何过敏史之间无明显相关性。脑膜瘤与自身免疫性疾病史呈负相关（OR = 0.59，95% CI = 0.38-0.92）。提示过敏和自身免疫性疾病对神经胶质瘤风险存在相互作用（p = 0.06），同时患有这两种疾病的受试者风险最低（OR = 0.24，95% CI = 0.14-0.42）。在特定条件中，哮喘和糖尿病显示出最一致的相关性（OR = 0.63，95%CI = 0.43-0.92和OR = 0.44，95%CI = 0.27-0.70）。我们的研究结果增加了过敏或自身免疫性疾病患者患神经胶质瘤风险降低的证据。这种关联的基础尚不清楚，但它们可能暗示了免疫因素在脑肿瘤发展中的作用。出版2002 Wiley-Liss，Inc.（匕首）
To explore a possible influence of the immune system in the development of brain tumors, we evaluated the relationship between history of allergies and autoimmune diseases and risk of brain tumors within a large, hospital-based case-control study. Cases (n 782) were patients recently diagnosed with glioma (n 489), meningioma (n = 197) or acoustic neuroma (n = 96) at hospitals in Boston, Phoenix and Pittsburgh (USA). Controls (n = 799) were patients hospitalized for a variety of nonmalignant conditions and frequency-matched to cases by hospital, age, sex, race/ethnicity and distance of residence from hospital. Research nurses collected data by personal interview of patients. Odds ratios (OR) and 95% confidence intervals (Cl) were calculated using unconditional logistic regression. There was a significant inverse association between glioma and history of any allergies (OR = 0.67, 95% Cl = 0.52-0.86) or autoimmune diseases (OR = 0.49, 95% Cl = 0.35-0.69). No significant associations were evident for meningioma or acoustic neuroma with history of any allergies. An inverse association was observed between meningioma and history of autoimmune diseases (OR = 0.59, 95% CI = 0.38-0.92). There was a suggestion of interaction between allergies and autoimmune diseases on risk of glioma (p = 0.06), with subjects having both conditions being at lowest risk (OR = 0.24, 95% Cl = 0.14-0.42). Among the specific conditions, asthma and diabetes showed the most consistent associations (OR = 0.63, 95% Cl = 0.43-0.92 and OR = 0.44, 95% Cl = 0.27-0.70, respectively). Our results add to evidence that persons with allergies or autoimmune diseases are at reduced risk of glioma. The basis of the associations is not clear, but they might imply a role of immunologic factors in the development of brain tumors. Published 2002 Wiley-Liss, Inc.(dagger)