Fatal neurogenic pulmonary edema in a patient with progressive multiple sclerosis
Fatal neurogenic pulmonary edema in a patient with progressive multiple sclerosis
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进行性多发性硬化症患者发生致命性神经源性肺水肿
DOI：
10.1177/1352458507087848
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Henning Laursen
中科院分区：
文献类型：
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作者：
S. Bramow;JC Faber;Christina Jacobsen;A. Kutzelnigg;Peter T. Patrikios;P. S. Sørensen;Hans Lassmann;Henning Laursen
我们报告一例致命的神经源性肺水肿进行性多发性硬化症（MS）。患者发生了1次孤立的复发样发作。6年后，疾病开始进展，持续5年，直到在睡眠中意外死亡。法医尸检显示肺水肿，神经病理学检查显示延髓呼吸中枢淋巴细胞和小胶质细胞浸润。在脊髓白色和脑灰质中发现了更多典型的脱髓鞘病变，沿着伴有弥漫性血管周围淋巴细胞浸润。进行性MS中的髓质炎症可能导致突发致命性呼吸衰竭。
We report a case of fatal neurogenic pulmonary edema in progressive multiple sclerosis (MS). The patient had one isolated relapse-like episode. Six years later progressive disease began, lasting 5 years until unexpected death during sleep. Medico-legal autopsy revealed pulmonary edema and neuropathological examination showed infiltrations with lymphocytes and microglia in the respiratory centers of the medulla. More classical demyelinated lesions were found in the white matter of spinal cord and in the gray matter of the brain along with disseminated perivascular lymphocytic infiltrates. Medullary inflammation in progressive MS may result in sudden fatal respiratory failure.