The Effects of Central Adiposity on Growth Hormone (GH) Response to GH-Releasing Hormone-Arginine Stimulation Testing in Men
The Effects of Central Adiposity on Growth Hormone (GH) Response to GH-Releasing Hormone-Arginine Stimulation Testing in Men
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DOI：
10.1210/jc.2008-1333
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发表时间：
2008-11-01
影响因子：
5.8
通讯作者：
Grinspoon, Steven
中科院分区：
文献类型：
--
作者：
Makimura, Hideo;Stanley, Takara;Grinspoon, Steven
内容：目的：我们的目的是评估体重和中枢和外周肥胖的具体措施的贡献，生长激素反应GHRH-精氨酸测试在瘦，超重和肥胖的男性。设计：共75名男性[平均年龄，44.3 +/-1.1岁;体重指数（BMI），28.8 +/- 0.7 kg/m2]。受试者被分为瘦型（BMI < 25 kg/m2; n = 23）、超重型（BMI >= 25且= 30 kg/m2; n = 24）。受试者还按腰围（WC）（≥ 102 cm，n = 28）分层。通过人体测量、双能X线吸收测定法（DEXA）和腹部计算机断层扫描（CT）对身体成分和局部肥胖进行评估。结果：瘦、超重和肥胖受试者的刺激GH峰值分别为36.4 +/- 5.4、16.6 +/- 2.9和7.6 +/- 0.9 μ g/L（所有比较P < 0.001）。在WC小于102 cm的受试者中，刺激的GH峰值为26.9 +/- 3.4 μ g/L，而在WC大于或等于102 cm的受试者中，刺激的GH峰值为7.9 +/- 0.9 μ g/L（P < 0.0001）。使用人体测量、DEXA和CT衍生的中心性肥胖测量的独立多变量模型表明，刺激GH峰值与中心性肥胖测量（包括WC、DEXA躯干脂肪和CT内脏脂肪）之间存在强相关性，控制年龄、BMI和更一般的肥胖测量。在包括年龄、BMI和臀围的模型中，WC与对GHRH-精氨酸的峰值GH反应独立相关。在这个模型中，BMI不再显着，峰值GH减少1.02微克/升，每增加1厘米的WC（P = 0.02）。结论：生长激素反应GHRH-精氨酸测试是减少超重和肥胖的受试者和中心腹部肥胖指数，包括WC，躯干脂肪，内脏脂肪组织呈负相关。使用腰围作为中心性肥胖的替代物，增加了GH反应的预测信息，与BMI无关。（临床内分泌代谢杂志93：4254-4260，2008）
Context: The relative contribution of central adiposity vs. weight on GH response to stimulation testing in obesity is not known.Objective: We aimed to assess the contribution of weight and specific measures of central and peripheral adiposity to GH response to GHRH-arginine testing in lean, overweight, and obese men.Design: A total of 75 men [mean age, 44.3 +/- 1.1 yr; body mass index (BMI), 28.8 +/- 0.7 kg/m(2)] were investigated. Subjects were classified as lean (BMI < 25 kg/m(2); n = 23), overweight (BMI >= 25 and = 30 kg/m(2); n = 24). Subjects were also stratified by waist circumference (WC) (= 102 cm, n = 28). Body composition and regional adiposity were assessed by anthropometrics, dual-energy x-ray absorptiometry (DEXA), and abdominal computed tomography (CT) scans.Results: Peak stimulated GH was 36.4 +/- 5.4, 16.6 +/- 2.9, and 7.6 +/- 0.9 mu g/liter among lean, overweight, and obese subjects, respectively (P < 0.001 for all comparisons). Peak stimulated GH was 26.9 +/- 3.4 mu g/liter among subjects with WC less than 102 cm compared to 7.9 +/- 0.9 mu g/liter among subjects with WC of 102 cm or greater (P < 0.0001). Separate multivariate models using anthropometric, DEXA, and CT-derived measures of central adiposity demonstrated strong associations between peak stimulated GH and measures of central adiposity including WC, trunk fat by DEXA, and visceral adiposity by CT, controlling for age, BMI, and more general measures of adiposity. WC was independently associated with peak GH response to GHRH-arginine in a model including age, BMI, and hip circumference. In this model, BMI was no longer significant, and peak GH was reduced 1.02 mu g/liter for each 1 cm increase in WC (P = 0.02).Conclusions: GH response to GHRH-arginine testing is reduced in both overweight and obese subjects and negatively associated with indices of central abdominal obesity including WC, trunk fat, and visceral adipose tissue. The use of waist circumference, as a surrogate for central adiposity, adds predictive information to the determination of GH response, independent of BMI. (J Clin Endocrinol Metab 93: 4254-4260, 2008)