Impact of Body Mass Index on Survival Outcome Among Women With Early Stage Triple-Negative Breast Cancer
Impact of Body Mass Index on Survival Outcome Among Women With Early Stage Triple-Negative Breast Cancer
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DOI：
10.1016/j.clbc.2012.07.013
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发表时间：
2012-10-01
影响因子：
3.1
通讯作者：
Gonzalez-Angulo, Ana M.
中科院分区：
文献类型：
--
作者：
Dawood, Shaheenah;Lei, Xiudong;Gonzalez-Angulo, Ana M.
这项回顾性研究的目的是调查肥胖对早期三重受体阴性乳腺癌（TN）女性的预后影响，TN是一种已知与预后不良相关的乳腺癌亚型。我们的研究结果表明，无论体重指数（BMI;通过将体重（公斤）除以身高（米）的平方计算）类别如何，患有TN疾病的女性预后不良。因此，这项研究的结果表明，肥胖不作为TN疾病患者的预后指标。背景资料：这项回顾性研究的目的是研究肥胖对早期三重受体阴性乳腺癌（TN）女性的预后影响，TN是一种已知与预后不良相关的乳腺癌亚型。患者和方法：确定了1990年至2010年期间诊断为I-III期TN乳腺癌的女性。根据BMI将队列分为3组：正常或体重不足（BMI < 25），超重（BMI 25-29.9）和肥胖（BMI >= 30）。使用Kaplan-Meier乘积限法估计无远处疾病生存期（DDFS），并使用对数秩统计进行组间比较。在调整患者和肿瘤特征后，使用考克斯比例风险模型确定DDFS和BMI的相关性。结果：在2311名患者中，我们确定了794名（34.3%）、692名（30%）和825名（35.7%）患者的BMI分别为< 25、25 - 29.9和>= 30。中位随访时间为39个月（范围：1-233个月）。BMI = 30的患者5年DDFS分别为61%、62%和62%。在多变量分析中，与BMI = 30的患者相比（HR = 0.99; 95%CI，83-1.18; P = 0.89），远处转移的风险没有显著增加。当模型按绝经状态分层时，得到了类似的结果。结论：无论BMI如何，TN患者预后不良。因此，这项研究的结果表明，肥胖不作为TN疾病患者的预后指标。
The aim of this retrospective study was to investigate the prognostic impact of obesity among women with early stage triple receptor-negative breast cancer (TN), a subtype of breast cancer known to be associated with poor prognosis. The results of our study indicate that women with TN disease have a poor prognostic outcome regardless of body mass index (BMI; computed by dividing the weight in kilograms by the square of the height in meters) category. As such, the results of this study indicate that obesity does not function as a prognostic indicator among patients with TN disease. Background: The aim of this retrospective study was to examine the prognostic impact of obesity among women with early stage triple receptor-negative breast cancer (TN), a subtype of breast cancer known to be associated with poor prognosis. Patients and Methods: Women with stage I-III TN breast cancer diagnosed between 1990 and 2010 were identified. The cohort was divided into 3 groups according to BMI: normal or underweight (BMI < 25), overweight (BMI 25-29.9), and obese (BMI >= 30). Distant disease-free survival (DDFS) was estimated using the Kaplan-Meier product limit method and compared across groups using log rank statistic. Cox proportional hazards models were then used to determine the association of DDFS and BMI after adjusting for patient and tumor characteristics. Results: Of 2311 patients, we identified 794(34.3%), 692 (30%), and 825 (35.7%), who had BMI of < 25, 25 to 29.9, and >= 30, respectively. Median follow-up was 39 months (range, 1-233 months). Five-year DDFS was 61%, 62%, and 62% among patients with BMI of = 30, respectively. On multivariate analysis, compared with patients with BMI = 30 (HR = 0.99; 95% CI, 83-1.18; P = .89) did not have a significant increase in risk of distant metastases. When the models were stratified by menopausal status similar results were obtained. Conclusions: Patients with TN disease have a poor prognostic outcome regardless of BMI category. As such, the results of this study indicate that obesity does not function as a prognostic indicator among patients with TN disease.