A twin study of rheumatoid arthritis in the Japanese population
A twin study of rheumatoid arthritis in the Japanese population
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DOI：
10.3109/14397595.2015.1135856
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发表时间：
2016-01-01
影响因子：
2.2
通讯作者：
Matsuda, Fumihiko
中科院分区：
文献类型：
--
作者：
Terao, Chikashi;Ikari, Katsunori;Matsuda, Fumihiko
目的：类风湿性关节炎（RA）是最常见的免疫相关性炎性关节炎，影响0.5-1.0%的人口。遗传和环境因素与RA发病相关。来自欧洲国家的双胞胎研究估计RA的遗传率为53- 65%。然而，没有双胞胎的研究已报告从亚洲countries.Methods：我们收集了共43个单卵和43个双卵双胞胎从7550例RA患者，并获得信息的RA状态的双胞胎对。我们的特点RA患者的双胞胎兄弟姐妹有RA。方差分量分析估计遗传在RA在日本population.Results：四个和一个RA患者超过43个单卵双胞胎（9.3%）和43个双卵双胞胎（2.3%），分别有双胞胎兄弟姐妹与RA。所有有血清学阳性资料且孪生兄弟患RA的患者均为血清学阳性。在AE和ACE模型中，RA的遗传度分别为62.2%和56.1%。估计的遗传力与欧洲人的报告，兼容与以前的重叠RA易感基因之间的日本和欧洲population.Conclusions：遗传力的RA发病在日本人口估计是可比的，在欧洲人口。
Objectives: Rheumatoid arthritis (RA) is the most common immune-related inflammatory arthritis affecting 0.5-1.0% of the population. Both genetic and environmental factors are associated with RA onset. Twin studies reported from European countries estimated heritability of RA as 53-65%. However, no twin studies have been reported from Asian countries.Methods: We collected a total of 43 monozygotic and 43 dizygotic twins from 7550 patients with RA and obtained information of RA status in the twin pairs. We characterized RA patients whose twin siblings had RA. Variance components analysis was performed to estimate heritability in RA in the Japanese population.Results: Four and one patients with RA over 43 monozygotic (9.3%) and 43 dizygotic twins (2.3%), respectively, had twin siblings with RA. All the patients whose information of seropositivity was available and whose twin siblings had RA were sero-positive. Heritability of RA was estimated as 62.2% and 56.1% in the AE and ACE models, respectively. The estimated heritability was comparable with those reported in the Europeans, compatible with previous overlap of RA susceptibility genes between Japanese and European populations.Conclusions: Heritability of RA onset in the Japanese population is estimated to be comparable with that in European populations.