Rib perichondrial autografts in full-thickness articular cartilage defects in rabbits.
Rib perichondrial autografts in full-thickness articular cartilage defects in rabbits.
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DOI：
10.1097/00003086-199202000-00040
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发表时间：
1992-02
影响因子：
4.2
通讯作者：
R. Coutts;S. Woo;D. Amiel;H. V. von Schroeder;M. Kwan
中科院分区：
文献类型：
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作者：
R. Coutts;S. Woo;D. Amiel;H. V. von Schroeder;M. Kwan
本研究研究了使用肋骨软骨膜移植物修复成年兔股骨内侧髁全层关节缺损的情况。移植物固定在从股骨髁上取出的直径 4 毫米的骨芯上。研究了两种术后治疗方案：一组进行随意的笼子活动（CAGE；n = 95），另一组接受两周的被动运动（PM；n = 73；每天八小时，每周五天），然后进行笼子活动。两组动物均在第 6、12、26 和 52 周时被处死。大多数动物在所有时间段和术后治疗组中都形成了类似于透明软骨的修复组织。 CAGE 组修复组织形成的总体成功率为 58%，PM 组为 56%。然而，随着时间的推移，新软骨成熟为几乎正常的透明关节软骨，II 型胶原蛋白的百分比从六周时的 55% 增加到一年时的 82%。随着愈合时间的增加，两组修复组织的复数剪切模量变得与正常软骨相似。两种治疗方式之间的剪切模量没有统计学差异。这些结果表明，源自肋骨软骨膜的软骨修复组织可以随着时间的推移成熟为透明关节软骨，并且在修复后一年内不会降解。
This study investigated the resurfacing of full-thickness articular defects in the adult rabbit medial femoral condyle using a rib perichondrial graft. The graft was secured to a 4-mm-diameter bone core removed from the femoral condyle. Two postoperative treatment protocols were studied: one group had ad libitum cage activity (CAGE; n = 95) and the other group received two weeks of passive motion (PM; n = 73; eight hours per day, five days per week) followed by cage activity. Animals in both groups were killed at six, 12, 26, and 52 weeks. Repair tissue resembling hyaline cartilage formed in a majority of animals at all time periods and in both postoperative treatment groups. The overall success rates in which repair tissue formed were 58% in the CAGE group and 56% in the PM group. However, over time, a maturation of the neocartilage into nearly normal hyaline articular cartilage was noted with the percentage of Type II collagen increasing from 55% at six weeks to 82% at one year. The complex shear modulus of the repair tissue for both groups became similar to normal cartilage with increased healing time. There was no statistical difference in shear moduli between the two treatment modalities. These results show that cartilage repair tissue derived from rib perichondrium could mature into hyaline articular cartilage over time and would not degrade by one year after repair.