Iron-oxide-based twin nanoplates with strong T-2 relaxation shortening for contrast-enhanced magnetic resonance imaging
Iron-oxide-based twin nanoplates with strong T-2 relaxation shortening for contrast-enhanced magnetic resonance imaging
复制标题
具有强 T-2 弛豫缩短作用的氧化铁基孪晶纳米板，用于对比增强磁共振成像
DOI：
10.1039/c8nr04995e
复制
发表时间：
2018
期刊：
影响因子：
6.7
通讯作者：
Gao Jinhao
中科院分区：
文献类型：
--
作者：
Wei Ruixue;Zhou Tiantian;Sun Chengjie;Lin Hongyu;Yang Lijiao;Ren Bin W;Chen Zhong;Gao Jinhao
氧化铁纳米材料由于具有良好的磁性和生物相容性，在过去的几十年中作为磁共振成像（MRI）造影剂（CA）得到了广泛的研究。然而，商业氧化铁纳米粒子为基础的CA遭受低T2弛豫，这显着限制了它们在生物医学领域的应用。在此，我们报道了一种新型的氧化铁纳米片（IOP）与一个有趣的孪生平面，这是通过种子生长制造。与传统的氧化铁（IO）球形纳米颗粒相比，氧化铁孪晶纳米片（IOP-13）具有更大的有效半径、更高的饱和磁化强度和更大的各向异性，导致它们在0.5 T下的上级T2弛豫率为571.21 mM-1 s-1，这比商业IO纳米颗粒高约6倍。体内MR成像表明IOP-13可用于肝脏成像和肝脏肿瘤诊断，具有高灵敏度和准确性，显示IOP-13作为下一代CA的巨大潜力。该研究为设计高性能T2造影剂提供了一种新的结构调整策略，拓展了氧化铁纳米粒子在生物学和材料学中的应用。
Iron oxide nanomaterials have been intensively investigated over the past few decades as magnetic resonance imaging (MRI) contrast agents (CAs) due to their favorable magnetism and excellent biocompatibility. However, commercial iron-oxide-nanoparticle-based CAs suffer from low T2 relaxivity, which significantly limits their applications in the biomedical field. Herein, we report a new type of iron oxide nanoplate (IOP) with an interesting twinning plane, which is fabricated via seed growth. Compared with the conventional iron oxide (IO) spherical nanoparticles, iron oxide twin nanoplates (IOP-13) have a larger effective radius, higher saturation magnetization, and greater anisotropy, resulting in their superior T2 relaxivity of 571.21 mM−1 s−1 at 0.5 T, which is about six times higher than that of commercial IO nanoparticles. In vivo MR imaging demonstrated that IOP-13 could be used for liver imaging and liver tumor diagnosis with high sensitivity and accuracy, revealing the great potential of IOP-13 as a next-generation CA. This work provides a novel strategy of structure tuning to devise high-performance T2 contrast agents, which expands the applications of iron oxide nanoparticles in biology and materials.