Regulation of the immune response in lymphatic filariasis:: perspectives on acute and chronic infection with Wuchereria bancrofti in South India
Regulation of the immune response in lymphatic filariasis:: perspectives on acute and chronic infection with Wuchereria bancrofti in South India
复制标题
DOI：
10.1046/j.1365-3024.2001.00399.x
复制
发表时间：
2001-07-01
影响因子：
2.2
通讯作者：
Kumaraswami, V
中科院分区：
文献类型：
--
作者：
Nutman, TB;Kumaraswami, V
描述淋巴丝虫病中的免疫反应不仅由于新的免疫介质和因子的迅速扩展的知识，而且由于用于定义和分类丝虫感染个体的新方法（特别是循环丝虫抗原检测）而变得复杂。通过使用检测循环抗原的血清中收集的一部分，在印度南部的班氏丝虫病流行地区的个人进行的许多免疫学研究，我们试图探讨通畅性的影响，抗原驱动的增殖和细胞因子反应，在外周血单核细胞的个人与淋巴丝虫感染的不同临床表现。此外，我们还提供了关于急性和慢性感染W之间差异的观点。Bancrofti和所提出的可能在通畅发生时调节免疫应答的机制。
Delineating the immune responses in lymphatic filariasis has been complicated not only by the rapidly expanding knowledge of new immunological mediators and effortors, but also by new methodologies (in particular, circulating filarial antigen detection) for defining and categorizing filarial-infected individuals. By using assays for circulating antigen in the sera collected as part of the many immunological studies performed on individuals in a Wuchereria bancrofti-endemic region of South India, we have attempted to explore the influence of patency on the antigen-driven proliferative and cytokine responses seen in peripheral blood mononuclear cells of individuals with varying clinical manifestations of lymphatic filarial infection. Moreover, we have provided perspectives on the differences between acute and chronic infection with W. bancrofti and suggested mechanisms that may underly the modulation of the immune response as patency occurs.