Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia
Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia
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DOI：
10.1016/s0002-9270(03)00053-4
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发表时间：
2003-04-01
影响因子：
9.8
通讯作者：
Tack, J
中科院分区：
文献类型：
--
作者：
Sarnelli, G;Caenepeel, P;Tack, J
功能性消化不良与固体或液体胃排空延迟之间的关系尚不清楚。本研究的目的是调查消化不良患者固体或液体胃排空延迟的患病率，并调查其与消化不良症状模式的关系。方法：在392例和330例功能性消化不良患者中，分别采用呼吸试验测量固体和液体胃排空，并对8种消化不良症状的严重程度进行评分。23%和35%的患者固体和液体胃排空延迟。多因素分析显示呕吐和餐后饱胀与固体排空延迟相关（OR分别为2.65，95%CI = 1.62-4.35和3.08，95%CI = 1.28-9.16）。当症状存在时（OR 3.5，95% CI = 1.57-8.68），相关或严重时（OR 2.504，95% CI = 1.57-8.68），餐后饱胀也与液体排空延迟的风险相关。95%CI = 1.41-4.65）和重度（OR 2.214，95%CI = 1.34-3.67）。严重的早饱感与液体排空延迟的风险相关（OR 1.902，95%CI = 1.90-3.30）。结论：消化不良患者的一个子集有固体或液体的胃排空延迟。固体的胃排空延迟总是与餐后饱胀和呕吐有关。液体排空延迟也与餐后饱胀感和严重的早饱感有关。
OBJECTIVES: The relationship between functional dyspepsia and delayed gastric emptying of solids or liquids is still unclear. The aim of the present study was to investigate in dyspeptic patients the prevalence of delayed gastric emptying for solids or for liquids and to investigate the relationship to the dyspepsia symptom pattern.METHODS: In 392 and 330 patients with functional dyspepsia, the solid and liquid gastric emptying, respectively, was measured using breath tests, and the severity of eight dyspeptic Symptoms was scored.RESULTS: Gastric emptying of solids and liquids were delayed in 23% and 35% of the patients. Multivariate analysis showed that the presence of vomiting and postprandial fullness was associated with delayed solid emptying (OR 2.65, 95% CI = 1.62-4.35 and OR 3.08, 95% CI = 1.28-9.16, respectively). Postprandial fullness was also associated with the risk of delayed liquid emptying when symptom was present (OR 3.5, 95% CI = 1.57-8.68), relevant or severe (OR 2.504. 95% CI = 1.41-4.65), and severe (OR 2.214, 95% CI = 1.34-3.67). Severe early satiety was associated with the risk of delayed liquid emptying (OR 1.902, 95% CI = 1.90-3.30).CONCLUSIONS: A subset of dyspeptic patients has delayed gastric emptying of solids or of liquids. Delayed gastric emptying of solids was constantly associated with postprandial fullness and with vomiting. Delayed emptying for liquids was also associated with postprandial fullness and with severe early satiety.