Subcellular distribution, and physical and immunological properties of hepatic alanine: glyoxylate aminotransferase isoenzymes in different mammalian species.
Subcellular distribution, and physical and immunological properties of hepatic alanine: glyoxylate aminotransferase isoenzymes in different mammalian species.
复制标题
肝丙氨酸的亚细胞分布以及物理和免疫特性：不同哺乳动物物种中的乙醛酸转氨酶同工酶。
DOI：
10.1016/0305-0491(82)90512-0
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
T. Noguchi
中科院分区：
文献类型：
--
作者：
Y. Takada;T. Noguchi
1. 肝丙氨酸的亚细胞分布以及物理和免疫学特性：用十种不同的哺乳动物物种检查了乙醛酸转氨酶同工酶 1 和 2。 2. 含有同工酶1的细胞器因物种而异；同工酶 1 位于过氧化物酶体、线粒体或两种细胞器中。相比之下，同工酶 2 仅在线粒体中发现，但在过氧化物酶体中未发现。 3. 在任何物种中，同工酶 1 的分子量约为 1。 80,000 具有两个相同的亚基和同工酶 2 约。 200,000 个，具有四个相同的亚基。 4. 在任何物种中，在同工酶 1 和同工酶 2 之间观察到免疫交叉反应，但在同工酶 1 和同工酶 2 之间没有观察到。
1. Subcellular distribution, and physical and immunological properties of hepatic alanine: glyoxylate aminotransferase isoenzymes 1 and 2 were examined with ten different mammalian species. 2. Intracellular organelles containing isoenzyme 1 varied from species to species; isoenzyme 1 was located in the peroxisomes, mitochondria or both organelles. In contrast, isoenzyme 2 was found only in the mitochondria but not in the peroxisomes. 3. In any species, isoenzyme 1 had molecular weight of approx. 80,000 with two identical subunits, and isoenzyme 2 approx. 200,000 with four identical subunits. 4. In any species, an immunological cross-reactivity was observed among isoenzymes 1 and among isoenzymes 2 but did not between isoenzymes 1 and isoenzymes 2.