Childhood social environment and risk of non-Hodgkin lymphoma in adults.
Childhood social environment and risk of non-Hodgkin lymphoma in adults.
复制标题
儿童社会环境与成人非霍奇金淋巴瘤的风险。
DOI：
10.1158/0008-5472.can-07-1751
复制
发表时间：
2007
期刊：
影响因子：
11.2
通讯作者：
Melbye,Mads
中科院分区：
文献类型：
--
作者：
Smedby,KarinEkstrom;Hjalgrim,Henrik;Chang,EllenT;Rostgaard,Klaus;Glimelius,Bengt;Adami,Hans-Olov;Melbye,Mads
在世界各地许多人群中，个人卫生和环境卫生的改善以及家庭规模的缩小与非霍奇金淋巴瘤 (NHL) 发病率的增加相平行。然而，同胞大小、出生顺序和拥挤是否与成人 NHL 风险相关尚不清楚。我们在一项大型斯堪的纳维亚人群病例对照研究中调查了家庭结构和儿童社会环境与 NHL 和 NHL 亚型风险之间的关系，该研究有 6,242 名年龄在 18 至 74 岁之间的参与者参与。详细的暴露信息是通过电话采访获得的。使用逻辑回归计算优势比 (OR) 和 95% 置信区间 (95% CI)，所有统计检验均为双边。与没有兄弟姐妹相比，有四个或更多兄弟姐妹与 NHL 风险中度增加相关（OR 1.34，95% CI 1.11-1.62，Ptrend < 0.001）。与最大的兄弟姐妹相比，有四个或更多兄弟姐妹的风险增加类似（OR 1.33，95% CI 1.12-1.59，Ptrend = 0.003），而弟弟妹妹的数量总体上不相关。这些关联独立于其他环境暴露，并且不因国家、年龄或性别而异。家庭拥挤程度也与 NHL 风险呈正相关。弥漫性大 B 细胞和 T 细胞淋巴瘤的结果略强于其他主要 NHL 亚型。我们的研究结果进一步证明，兄弟姐妹规模大、出生顺序晚和儿童拥挤与 NHL 风险升高有关。影响机制可能与发病年龄早、特定感染频率高或儿童期总微生物暴露有关。 [癌症研究 2007;67(22):11074–82]
Better hygiene and sanitation and decreasing family size parallel the increasing incidence of non–Hodgkin lymphoma (NHL) in many populations around the world. However, whether sibship size, birth order, and crowding are related to adult NHL risk is not clear. We investigated how family structure and childhood social environment were related to the risk of NHL and NHL subtypes in a large Scandinavian population–based case control study with 6,242 participants aged 18 to 74 years. Detailed exposure information was obtained through telephone interviews. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using logistic regression, and all statistical tests were two-sided. Having four or more siblings was associated with a moderately increased risk of NHL, compared with having no siblings (OR 1.34, 95% CI 1.11-1.62,Ptrend< 0.001). Having four or more older siblings was associated with a similar risk increase (OR 1.33, 95% CI 1.12-1.59,Ptrend= 0.003) compared with being the oldest, whereas number of younger siblings was unrelated overall. The associations were independent of other environmental exposures and did not vary by country, age, or sex. High household crowding was also positively associated with risk of NHL. Results were slightly stronger for diffuse large B-cell and T-cell lymphomas than for other major NHL subtypes. Our findings add to the evidence that large sibship size, late birth order, and childhood crowding are associated with an elevated risk of NHL. Effect mechanisms may be related to early age at onset and high frequency of specific infections or total microbial exposure in childhood. [Cancer Res 2007;67(22):11074–82]