Diagnostic biomarkers for oral and periodontal diseases.
Diagnostic biomarkers for oral and periodontal diseases.
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DOI：
10.1016/j.cden.2005.03.009
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发表时间：
2005-07-01
影响因子：
--
通讯作者：
Giannobile, William V
中科院分区：
文献类型：
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作者：
Taba, Mario Jr;Kinney, Janet;Giannobile, William V
本文概述了牙周病诊断的临床参数和疾病过程的生物标志物，讨论了疾病的生物标志物的使用，可以在组织，细胞和分子水平上识别，并可在口腔液，如唾液和龈沟液测量。从这些生物液体中鉴定出的生物标志物包括微生物、宿主反应和结缔组织相关分子，这些分子可以靶向局部牙槽骨吸收的特定途径。提出了使用微阵列和微流体技术的基于口腔流体的诊断的未来前景。
This article provides an overview of periodontal disease diagnosis that uses clinical parameters and biomarkers of the disease process.This article discusses the use of biomarkers of disease that can be identified at the tissue, cellular, and molecular levels and that are measurable in oral fluids such as saliva and gingival crevicular fluid. Biomarkers identified from these biologic fluids include microbial, host response, and connective tissue-related molecules that can target specific pathways of local alveolar bone resorption. Future prospects for oral fluid-based diagnostics that use micro-array and microfluidic technologies are presented.