Frailty index as a measure of biological age in a Chinese population
Frailty index as a measure of biological age in a Chinese population
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DOI：
10.1093/gerona/60.8.1046
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发表时间：
2005-08-01
影响因子：
5.1
通讯作者：
Ho, SC
中科院分区：
文献类型：
--
作者：
Goggins, WB;Woo, J;Ho, SC
背景脆弱指数的概念，在加拿大老年人口的生物学年龄，而不是实足年龄的指标，在中国老年人口进行了测试，以确定它是否适用于不同的种族和文化setting. Methods。一个数据集，包括62个身体，心理和社会经济变量从一个队列的2032人70岁及以上（999名男性，1033名女性）。采用Cramer-von Mises拟合优度检验评价该指数的分布，并采用多元线性回归评估其与年龄和性别的关系。根据年龄对平均虚弱指数和性别的逆回归计算每个参与者的生物学年龄。采用考克斯比例风险回归模型评估生物学年龄预测死亡的能力。脆弱性指数的分布最接近威布尔分布。虚弱指数随着年龄的增长而增加，直到80年代中期，当它稳定下来时，每个年龄组的女性都高于男性。生物学年龄的分布比实际年龄的分布更广，它强烈地预测了死亡。女性在特定时间的死亡率估计比相同实际年龄和虚弱程度的男性低20%。这项研究证实了稳健的概念和方法计算脆弱指数在老年加拿大人口。它还表明，预期寿命的性别差异可能有一个独立于虚弱的潜在遗传基础。
Background. The concept of a frailty index, developed in Canadian elderly populations as an indicator of biological age as opposed to chronological age, was tested in an elderly Chinese population to determine whether it is applicable in a different ethnic and cultural setting.Methods. A data set including 62 physical, psychological, and socioeconomic variables from a cohort of 2032 persons 70 years and older (999 men, 1033 women) was used. The distribution of the index was evaluated using the Cramer-von Mises goodness-of-fit test, and multiple linear regression was used to assess its relationship with age and sex. A biological age for each participant was calculated based on an inverse regression of age on mean frailty index and sex. The Cox proportional hazards regression model was used to assess the ability of biological age to predict death.Results. The distribution of the frailty index most closely resembled a Weibull distribution. The frailty index increased with age until the mid-80s, when it leveled off, and was higher in women than men for each age group. The distribution of biological age is wider than that for chronological age, and it strongly predicted death. Women had an estimated 20% lesser chance of dying at a given time than did men of the same chronological age and degree of frailty.Conclusions. The study confirms the robustness of the concept and method of calculating the frailty index developed in elderly Canadian populations. It also suggests that the sex difference in life expectancy may have an underlying genetic basis independent of frailty.