Identification of a Novel HIV-1 Unique CRF01_AE/C Recombinant in Yan'an City, Shaanxi Province.
Identification of a Novel HIV-1 Unique CRF01_AE/C Recombinant in Yan'an City, Shaanxi Province.
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陕西省延安市新型HIV-1独特CRF01_AE/C重组体的鉴定。
DOI：
10.1089/aid.2020.0174
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发表时间：
2020
影响因子：
1.5
通讯作者：
Zhou Yan-Heng
中科院分区：
文献类型：
--
作者：
Cheng Si-Wei;Qi Feng;Xie Ying-Na;Wang Na;Chen Yan-Ping;Gao Li-Li;Chen Xin;Zhou Yan-Heng
在中国不断发现各种各样的HIV-1重组体。全面监测HIV-1的遗传多样性对于了解HIV-1的分子流行病学和控制HIV-1的流行具有重要意义。本研究从陕西省延安市一名经异性传播感染HIV-1的女性患者中分离到一株新的HIV-1特异性CRF01_AE/C重组体（19 YA 001）。近全长基因组分析表明，19 YA 001在vif/vpr区观察到两个断裂点，将其分为两个CRF01_AE和一个C片段。这是延安市首次发现HIV-1亚型特征。这一独特的重组株可能暗示延安市HIV-1的遗传多样性是复杂的。但是，样本量太小。进一步更大规模的HIV-1分子流行病学研究是迫切需要提供一个更好的了解HIV-1的多样性和传播在这一地区。
A wide variety of HIV-1 recombinants are constantly discovered in China. Comprehensively monitoring the genetic diversity of HIV-1 is very essential for understanding the molecular epidemiology and controlling the spread of the HIV-1 epidemic. In this study, we presented a novel HIV-1 unique CRF01_AE/C recombinant (19YA001) isolated from a female patient infected HIV-1 through heterosexual transmission in Yan'an city, Shaanxi province. The near full-length genome analyses showed 19YA001 was divided into two CRF01_AE and one C segments by two breakpoints observed in thevif/vprregion. To date, this is the first report revealing the characteristic of HIV-1 subtype in Yan'an city. And this unique recombinant strain might imply that the genetic diversity of HIV-1 in Yan'an city is complex. However, the sample size is too small. Further larger studies of HIV-1 molecular epidemiology are urgently needed to provide a better understanding of HIV-1 diversity and transmission in this region.