Minireview: nuclear receptor coregulators of the p160 family: insights into inflammation and metabolism.
Minireview: nuclear receptor coregulators of the p160 family: insights into inflammation and metabolism.
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DOI：
10.1210/me.2015-1005
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发表时间：
2015-02
影响因子：
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通讯作者：
David A. Rollins;Maddalena Coppo;Inez Rogatsky
中科院分区：
文献类型：
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作者：
David A. Rollins;Maddalena Coppo;Inez Rogatsky
核受体辅激活因子（NCOA）是多功能转录共调节因子，可调节越来越多的信号激活转录因子。 p160 家族成员 (NCOA1/2/3) 越来越多地被认为是许多生理过程中重要且非冗余的参与者。特别是，越来越多的证据表明，这些核心调节因子在体内平衡和疾病中的炎症和代谢途径中发挥着关键作用。鉴于代谢组织的慢性炎症（“元炎症”）是肥胖、胰岛素抵抗、心血管疾病和相关合并症广泛流行的驱动力，破译 NCOA 在“正常”与“病理性”炎症以及代谢过程中的作用确实是一个具有极高生物医学重要性的课题。在这里，我们回顾了关于 NCOA1/2/3 在炎症和代谢中与核受体作用等相关的多效性功能的不断发展的、有时甚至是矛盾的文献。然后，我们简要讨论一旦更好地了解了 NCOA 的分子和生理作用，NCOA 作为疾病和/或可能的治疗靶标的预测标记的潜在效用。
Nuclear receptor coactivators (NCOAs) are multifunctional transcriptional coregulators for a growing number of signal-activated transcription factors. The members of the p160 family (NCOA1/2/3) are increasingly recognized as essential and nonredundant players in a number of physiological processes. In particular, accumulating evidence points to the pivotal roles that these coregulators play in inflammatory and metabolic pathways, both under homeostasis and in disease. Given that chronic inflammation of metabolic tissues ("metainflammation") is a driving force for the widespread epidemic of obesity, insulin resistance, cardiovascular disease, and associated comorbidities, deciphering the role of NCOAs in "normal" vs "pathological" inflammation and in metabolic processes is indeed a subject of extreme biomedical importance. Here, we review the evolving and, at times, contradictory, literature on the pleiotropic functions of NCOA1/2/3 in inflammation and metabolism as related to nuclear receptor actions and beyond. We then briefly discuss the potential utility of NCOAs as predictive markers for disease and/or possible therapeutic targets once a better understanding of their molecular and physiological actions is achieved.