Comparison of three rat models of cerebral vasospasm
Comparison of three rat models of cerebral vasospasm
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DOI：
10.1152/ajpheart.00616.2002
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发表时间：
2002-12-01
影响因子：
4.8
通讯作者：
Zhang, JH
中科院分区：
文献类型：
--
作者：
Gules, I;Satoh, M;Zhang, JH
大量的大鼠模型已被用于研究蛛网膜下腔出血诱导的脑血管痉挛;然而，关于哪种选择方法适用于该种属存在争议。本研究旨在提供关于三种最流行的蛛网膜下腔出血大鼠模型的广泛信息：血管内穿刺模型、单次出血模型和双次出血模型。在这项研究中，选择基底动脉和后交通动脉进行组织病理学检查和形态计量学分析。血管内穿刺模型和单次出血模型均发生了明显程度的血管痉挛，与双次出血模型相比，其严重程度较低。血管内穿刺模型和双重出血模型均在后交通动脉中比在基底动脉中发生更多的血管痉挛。血管内穿刺模型具有显著高的死亡率和出血量的高变异性。总之，本研究表明，大鼠双出血模型是一种更合适的工具，研究机制和治疗方法，因为它准确地与血管痉挛的时间过程。在人类身上。
A substantial number of rat models have been used to research subarachnoid hemorrhage-induced cerebral vasospasm; however, controversy exists regarding which method of selection is appropriate for this species. This study was designed to provide extensive information about the three most popular subarachnoid hemorrhage rat models: the endovascular puncture model, the single-hemorrhage model, and the double-hemorrhage model. In this study, the basilar artery and posterior communicating artery were chosen for histopathological examination and morphometric analysis. Both the endovascular puncture model and single-hemorrhage model developed significant degrees of vasospasm, which were less severe when compared with the double-hemorrhage model. The endovascular puncture model and double-hemorrhage model both developed more vasospasms in the posterior communicating artery than in the basilar artery. The endovascular puncture model has a markedly high mortality rate and high variability in bleeding volume. Overall, the present study showed that the double-hemorrhage model in rats is a more suitable tool with which to investigate mechanism and therapeutic approaches because it accurately correlates with the time courses for vasospasm. in humans.