The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities.
The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities.
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DOI：
10.1186/s12943-020-01263-w
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发表时间：
2021-01-18
期刊：
影响因子：
37.3
通讯作者：
Blanco S
中科院分区：
文献类型：
--
作者：
Nombela P;Miguel-López B;Blanco S
RNA修饰最近成为基因表达程序的关键转录后调节因子。在理解RNA修饰在调节编码和非编码RNA加工和功能中的功能作用方面取得了重大进展，这反过来又彻底塑造了不同的基因表达程序。它们影响不同的生物过程，许多这些修饰的正确沉积是正常发育所必需的。其沉积的改变与包括癌症在内的几种疾病有关。在这篇综述中，我们集中在编码和非编码RNA中N6-甲基腺苷（m6 A），5-甲基胞嘧啶（m5 C）和假尿苷（pseudouridine）的出现，并描述它们在癌症中的生理病理作用。我们将重点介绍这些转录后修饰如何影响肿瘤发展、维持和进展的机制的最新见解。最后，我们将总结小分子抑制剂的最新进展，这些抑制剂靶向特定的写入器或擦除器，以逆转癌细胞的表位转录组及其治疗潜力。
RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding RNA processing and function, which in turn thoroughly shape distinct gene expression programmes. They affect diverse biological processes, and the correct deposition of many of these modifications is required for normal development. Alterations of their deposition are implicated in several diseases, including cancer. In this Review, we focus on the occurrence of N6-methyladenosine (m6A), 5-methylcytosine (m5C) and pseudouridine (Ψ) in coding and non-coding RNAs and describe their physiopathological role in cancer. We will highlight the latest insights into the mechanisms of how these posttranscriptional modifications influence tumour development, maintenance, and progression. Finally, we will summarize the latest advances on the development of small molecule inhibitors that target specific writers or erasers to rewind the epitranscriptome of a cancer cell and their therapeutic potential.
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影响因子：
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3.7
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Diaz JJ