Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions.
Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions.
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一种外用中药治疗乳腺癌前病变的药效学及药物化学
DOI：
10.1155/2017/6235027
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Ma M
中科院分区：
文献类型：
--
作者：
Chen R;Zhang G;Ma Y;Bie F;Fan H;Ma M
乳腺内消霜是治疗乳腺癌前病变的传统中药方剂。本研究旨在探讨RYNXC及其多组分的体内抗肿瘤作用。将32只SD大鼠随机分为空白对照组（BC）、乳腺癌前病变模型组（MODEL）、三苯氧胺组（TAM）和乳炎内消霜组（RYNXC）。TAM组给予他莫昔芬干预; RYNXC组给予乳炎内消霜干预。色谱分离采用高效液相色谱-质谱联用技术。与模型组比较，RYNXC组的红细胞聚集指数（EAI）、红细胞压积（HCT）、纤维蛋白原（FIB）、脾脏系数和子宫系数均有显著改善。RYNXC组和TAM组病理组织中可见不典型增生; MODEL组可见原位导管癌。根据HPLC-MS数据对15个化合物进行了结构鉴定，包括有机酸、鞣质、生物碱、挥发油、蒽醌和黄酮类化合物。本研究结果表明，乳腺癌消胶囊是治疗乳腺癌前病变的有效中药配方，为制定其质量标准和药理作用提供了科学依据。这将有利于RYNXC的临床应用。
Ruyan Neixiao Cream (RYNXC) is a traditional Chinese herbal formula for treating mammary precancerous disease. This study was carried out to investigate in vivo anticancer effect of RYNXC and multiple constituents. 32 virginal Sprague-Dawley rats were randomly divided into blank control group (BC), mammary precancer models group (MODEL), tamoxifen group (TAM), and Ruyan Neixiao Cream group (RYNXC). TAM was intervened by tamoxifen; RYNXC was intervened by Ruyan Neixiao Cream. The chromatographic separation was performed by high performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). RYNXC showed significant improvement in erythrocyte aggregation index (EAI), hematocrit (HCT), fibrinogen (FIB), spleen coefficient, and uterus coefficient compared with MODEL. In RYNXC and TAM groups, atypical hyperplasia was observed in pathological mammary tissues; meanwhile in MODEL group, ductal carcinoma was observed in situ. Moreover, fifteen compounds were characterized according to HPLC-MS data, including organic acids, tannin, alkaloid, volatile oil, anthraquinones, and flavonoids. The study suggests that RYNXC was an effective Chinese herbal formula for mammary precancerous lesions and provides a scientific basis for the quality standard and the pharmacology of RYNXC. It will be beneficial to the future clinical application of RYNXC.
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影响因子：
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