A novel formulation for blood trauma prediction by a modified power-law mathematical model
A novel formulation for blood trauma prediction by a modified power-law mathematical model
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DOI：
10.1007/s10237-005-0005-y
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发表时间：
2005-12-01
影响因子：
3.5
通讯作者：
Del Gaudio, C
中科院分区：
文献类型：
--
作者：
Grigioni, M;Morbiducci, U;Del Gaudio, C
随着人工器官使用的增加，血液损伤引起了越来越多的临床关注。血液创伤实际上是植入医疗装置和使用生命维持设备造成的主要并发症。红细胞损伤预测模型为人工器官的设计和评估提供了重要的信息，因为它们的正确使用和实施被认为为提高安全性和有效性提供了明确和合理的指导。目前采用的幂律剪切诱导溶血预测模型对于先前施加的应力值的累积效应缺乏敏感性。提出了另一种模型，其中定义了一个力学量，能够描述红细胞在非稳态应力条件下持续的血液损伤，并考虑到负载历史。所提出的公式预测的趋势与现有的实验数据相同。所获得的结果必须被认为是对这种改进的红细胞损伤预测模型的基本假设的初步验证。到目前为止，设计进一步的实验来验证所提出的损伤函数的必要性与现有系统固有的限制相冲突，以使时变剪切应力完全得到控制。
With the increasing use of artificial organs, blood damage has been raising ever more clinical concern. Blood trauma is in fact a major complication resulting from the implantation of medical devices and the use of life support apparatuses. Red blood cells damage predictive models furnish critical information on both the design and the evaluation of artificial organs, because their correct usage and implementation are thought to provide clear and rational guidance for the improvement of safety and efficacy. The currently adopted power-law shear-induced haemolysis prediction model lacks sensitivity with respect to the cumulative effect of previously applied stress magnitudes. An alternative model is proposed where a mechanical quantity was defined, able to describe the blood damage sustained by red cells under unsteady stress conditions, taking into account the load history. The proposed formulation predicted the same trend as the available experimental data. The obtained results have to be considered a preliminary validation of the basic hypothesis of this modified red blood cell damage prediction model. To date, the necessity to design further experiments to validate the proposed damage function clashes with the limitations inherent to current systems to get the time-varying shear stress completely under control.