The method of determination must be considered in interpreting blood cholesterol levels.
The method of determination must be considered in interpreting blood cholesterol levels.
复制标题
在解释血液胆固醇水平时必须考虑测定方法。
DOI：
10.1001/jama.1986.03380200105030
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
M. Ruddel
中科院分区：
文献类型：
--
作者：
D. Blank;J. Hoeg;M. Kroll;M. Ruddel
根据最近的临床试验结果，鼓励医生筛查和治疗高胆固醇血症患者。由于脂质研究诊所（LRC）的数据已用于定义应接受治疗的患者人群，因此将LRC胆固醇结果与使用两种常用临床实验室仪器获得的结果进行了比较。与LRC法相比，Technicon SMAC和Du蓬特aca均存在正偏倚。因此，通过这些常规使用的方法测定的胆固醇浓度大于265 mg/dL（6.85 mmol/L）的许多患者通过LRC方法测定的水平明显较低。这些结果不仅表明，严格的实验室间标准化，需要符合LRC参考值，但他们也表明，临床医生应该知道这些方法的考虑时，决定治疗高胆固醇血症。
Based on the results of recent clinical trials, physicians have been encouraged to screen and treat patients for hypercholesterolemia. Since the data from the Lipid Research Clinics (LRC) have been used to define the patient population that should be treated, a comparison of LRC cholesterol results with those obtained with two commonly used clinical laboratory instruments was performed. Both the Technicon SMAC and the Du Pont aca had positive bias compared with the LRC method. Therefore, many patients with cholesterol concentrations greater than 265 mg/dL (6.85 mmol/L) as determined by these routinely used methods have markedly lower levels determined by LRC methods. These findings not only indicate that rigorous interlaboratory standardization is required to conform to LRC reference values, but they also suggest that the clinician should be aware of these methodological considerations when the decision to treat hypercholesterolemia is made.