Immune function in intrauterine growth retardation
Immune function in intrauterine growth retardation
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DOI：
10.1016/s0271-5317(98)00013-x
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发表时间：
1998-02-01
影响因子：
4.5
通讯作者：
Karuga-Koinange, W
中科院分区：
文献类型：
--
作者：
Neumann, CG;Stiehm, ER;Karuga-Koinange, W
对肯尼亚2组宫内发育迟缓儿和正常体重足月儿进行为期一年的纵向研究，以确定宫内营养不良和其他营养缺乏对免疫功能的影响。研究了三个出生体重组：< 2500 gm（小于或等于第3百分位数）; 2500-2799 gm（第3至第10百分位数）;以及大于或等于2800 gm（>第10百分位数）。通过测定B淋巴细胞和血清IgG、IgM、伊加和IgE水平来研究B细胞功能。通过测量淋巴细胞数量、E玫瑰花结技术测量T细胞百分比和绝对数量、淋巴细胞对PHA的反应性以及皮内PPD对BCG疫苗的反应来研究T细胞功能。同时获得了产妇和婴儿营养研究。出生时B细胞和免疫球蛋白是正常的，除了41名婴儿中有7名在他们的脐带血中IgE水平升高外，所有组都是可比的。7个月时，在宫内生长迟缓婴儿中达到成人IgG、IgM和IgE水平。他们的母亲比对照组的母亲有显着更高的IgG水平。IUGR组出生时总淋巴细胞计数、T细胞和T细胞百分比均显著降低。在最小（小于或等于2500 g）出生体重组中，这种异常持续至1年。IUGR组皮肤对PPD无反应的发生率高于对照组。细胞介导的免疫力与出生体重、出生时血液中的铁和硫胺素水平以及6个月和12个月时的叶酸、血红蛋白、吡哆醇和核黄素水平显著相关。(C)1998年爱思唯尔科学公司
A one-year longitudinal study was carried out on 2 groups of Kenyan intrauterine growth retarded infants and normal weight full-term infants to determine the effects of intrauterine malnutrition and other nutrient deficiencies on immune function. Three birth weight groups were studied: < 2500 gm (less than or equal to 3rd percentile); 2500-2799 gm (3rd to 10th percentile); and greater than or equal to 2800 (> 10th percentile). B cell function was studied by determination of B lymphocytes and serum levels of IgG, IgM, IgA and IgE. T-cell function was studied by measuring lymphocyte numbers, the percent and absolute number of T-cells by E-rosette technique, lymphocyte responsiveness to PHA and the intradermal PPD responses to BCG vaccine. Maternal and infant nutritional studies were obtained concurrently. At birth B cells and immunoglobulins were normal and comparable in all groups except that seven of 41 infants had elevated IgE levels in their cord blood. By 7 months adult levels of IgG, IgM and IgE were achieved in the intrauterine growth retarded infants. Their mothers had significantly higher levels of IgG than the control mothers. Total lymphocyte counts, T-cells and percent T-cells were significantly reduced at birth in the IUGR groups. This abnormality persisted until one year in the smallest (less than or equal to 2500 g) birthweight group. The IUGR infants had a higher incidence of cutaneous anergy to PPD than did control infants. Cell-mediated immunity correlated significantly with birthweight, blood levels of iron and thiamin at birth and with folate, hemoglobin, pyridoxine and riboflavin at 6 and 12 months. (C) 1998 Elsevier Science Inc.