Mechanisms of exTreg induction.
Mechanisms of exTreg induction.
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DOI：
10.1002/eji.202049123
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发表时间：
2021-08
影响因子：
5.4
通讯作者：
Bromberg JS
中科院分区：
文献类型：
--
作者：
Saxena V;Lakhan R;Iyyathurai J;Bromberg JS
CD 4 + CD 25 + Foxp 3+调节性T细胞（TCRs）通过调节免疫应答和解决炎症在维持免疫系统中发挥重要作用。T细胞通过抑制其他免疫细胞和介导外周自身耐受来发挥其功能。在稳态条件下，T细胞是稳定的T细胞群。然而，在炎性环境下，T细胞转化为CD 4 + CD 25 lowFoxp 3low细胞。这些细胞被称为“exTreg”或“exFoxp 3”细胞。Treg转变为exT细胞的分子机制仍不完全清楚。不一致性可能是由于缺乏一致的生物标志物来定义一般的Treg亚群和特别的外切T细胞。在这篇综述中，我们总结了已知的标记物的TCLG和负责exTreg生成的因素，包括细胞因子，信号通路，转录因子和表观遗传机制。我们还确定了研究表明，在各种疾病和来源的exTHBG的存在。了解Treg向exTlag转变的生物学将有助于设计基于Treg的治疗方法。调节性T细胞（Regulatory T cells，Tcells）的可塑性是其免疫抑制功能所必需的。在稳态期间，Treg稳定性通过几种因素的相互作用来维持。炎症诱导的扰动影响Treg稳定性，导致其转化为exTcl 3/exFoxp 3。我们提供了exTreg生成的机制概述。
CD4+CD25+Foxp3+ regulatory T cells (Tregs) play an important role in the maintenance of the immune system by regulating immune responses and resolving inflammation. Tregs exert their function by suppressing other immune cells and mediating peripheral self-tolerance. Under homeostatic conditions, Tregs are stable T cell populations. However, under inflammatory environments, Tregs are converted to CD4+CD25lowFoxp3low cells. These cells are termed “exTreg” or “exFoxp3” cells. The molecular mechanism of Treg transition to exTregs remains incompletely understood. Uncertainties might be explained by a lack of consensus of biological markers to define Treg subsets in general and exTregs in particular. In this review, we summarize known markers of Tregs and factors responsible for exTreg generation including cytokines, signaling pathways, transcription factors, and epigenetic mechanisms. We also identify studies demonstrating the presence of exTregs in various diseases and sources of exTregs. Understanding the biology of Treg transition to exTregs will help in designing Treg-based therapeutic approaches. The plasticity of regulatory T cells (Tregs) is required for their function of immune suppression. During homeostasis, Treg stability is maintained by an interplay of several factors. Inflammation induced perturbations affect Treg stability resulting in their conversion to exTregs/exFoxp3. We provide a mechanistic overview of exTreg generation.
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影响因子：
8.8
作者：
Fan MY;Low JS;Tanimine N;Finn KK;Priyadharshini B;Germana SK;Kaech SM;Turka LA
通讯作者：
Turka LA
影响因子：
30.5
作者：
Charbonnier LM;Wang S;Georgiev P;Sefik E;Chatila TA
通讯作者：
Chatila TA
影响因子：
4.4
作者：
Burchill, Matthew A.;Yang, Jianying;Farrar, Michael A.
通讯作者：
Farrar, Michael A.
控制FOXP3基因座中的顺式元素对调节T细胞身份的遗传控制。
影响因子：
64.5
作者：
Feng Y;Arvey A;Chinen T;van der Veeken J;Gasteiger G;Rudensky AY
通讯作者：
Rudensky AY
影响因子：
32.4
作者：
Delacher, Michael;Imbusch, Charles D.;Feuerer, Markus
通讯作者：
Feuerer, Markus