Incorporating Historical Controls in Testing for a Trend in Proportions
Incorporating Historical Controls in Testing for a Trend in Proportions
复制标题
将历史控制纳入比例趋势测试中
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
T. Yanagawa
中科院分区：
文献类型：
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作者：
D. Hoel;T. Yanagawa
摘要在啮齿类动物终生生物测定中，化学品的致癌活性测试已经产生了大量关于几种小鼠和大鼠的数据。由于在重复实验中使用固定方案，因此有机会在当前实验的分析中使用此历史数据。考虑将历史对照数据统计纳入当前对照组，以增加检验的把握度。当处理罕见类型的肿瘤时，这一点尤其重要，因为毒理学家将非常重视治疗组中的肿瘤发生率。在实验中，假设在两个处理水平和一个对照组下对三组动物（每组约50只动物）进行试验。假设每个治疗组的应答为二项式。此外，假设对照组中具有肿瘤的动物的概率具有根据历史对照数据确定的β分布。一些作者（Demp...
Abstract The testing of chemicals for carcinogenic activity in lifetime rodent bioassays has produced a large amount of data on a few strains of mice and rats. Because of the use of fixed protocols in repeated experiments, the opportunity presents itself for using this historical data in the analysis of a current experiment. What has been considered is the statistical incorporation of the historical control data into the current control group to increase the power of the test. This is especially relevant when dealing with tumors of a rare type where the toxicologist will place great significance on their occurrence in a treatment group. Experimentally it is assumed that three groups of about 50 animals each are tested at two treatment levels and a control. The response for each treatment group is assumed to be binomial. Further it is assumed that the probability of an animal with a tumor in the control group has a beta distribution that is determined from the historical control data. Several authors (Demp...