Biochemistry of the glycosyl-phosphatidylinositol membrane protein anchors.
Biochemistry of the glycosyl-phosphatidylinositol membrane protein anchors.
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DOI：
10.1042/bj2440001
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发表时间：
1987-05
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影响因子：
--
通讯作者：
Martin G. Low
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文献类型：
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作者：
Martin G. Low
1. (a)膜蛋白的锚定。人们普遍认为，大多数生物膜的主要结构特征是脂质双分子层，蛋白质要么结合在极性表面，要么在一定程度上穿透双分子层内部。将后一组蛋白质（即整体膜蛋白）保持在膜中的净力是相对疏水和极性多肽结构域分别与脂质双分子层疏水核心和周围介质之间相互作用的平衡（Capaldi, 1982; Singer & Nicolson, 1972）。这些力不仅对这些蛋白质附着在膜上很重要，而且还允许蛋白质采用正确的构象和跨膜取向，从而使其功能（即溶质运输，信号转导，粘附等）能够正确执行。膜蛋白在性质和(a)(b)(c)上有显著差异。
1. Introduction (a) Anchoring of membrane proteins. It is generally accepted that the predominant structural feature of most biological membranes is a lipid bilayer with proteins either bound to the polar surface or penetrating the bilayer interior to some extent. The net force which holds the latter group of proteins (ie, integral membrane proteins) in the membrane is the balance of interactions between relatively hydrophobic and polar polypeptide domains with the hydrophobic core of the lipid bilayer and the surrounding medium, respectively (Capaldi, 1982; Singer & Nicolson, 1972). These forces are not only important for attaching these proteins to the membrane, but also permit the protein to adopt its correct conformation and transmembrane orientation so that its function (ie solute transport, signal transduction, adhesion, etc.) can be performed correctly. Membrane proteins vary markedly in the nature and (a)(b)(c)