Diagnostic cellular organization features extracted from autofluorescence images
Diagnostic cellular organization features extracted from autofluorescence images
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DOI：
10.1364/ol.32.003305
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发表时间：
2007-11-15
期刊：
影响因子：
3.6
通讯作者：
Georgakoudi, Irene
中科院分区：
文献类型：
--
作者：
Levitt, Jonathan M.;Hunter, Martin;Georgakoudi, Irene
深度分辨的NADH自体荧光图像显示区分正常和癌前工程组织。观察到这些图像的功率谱密度（PSD）的逆幂律行为，表明线粒体NADH在长度尺度1 - 10 μ m处的自仿射组织。PSD函数的幂指数随组织深度和癌前状态而显著变化，从而深入了解与癌前病变相关的形态学变化，并为鳞状上皮病变和肿瘤的无创临床诊断提供了巨大潜力。(c)2007年，美国光学学会。
Depth-resolved NADH autofluorescence images are shown to differentiate between normal and precancerous engineered tissues. An inverse power law behavior of the power spectral density (PSD) of these images is observed, indicating a self-affine organization of mitochondrial NADH at length scales 1 - 10 mu m. Power exponents of the PSD functions vary significantly with tissue depth and precancerous state, giving insight into the morphological changes associated with precancerous lesions and providing substantial potential for noninvasive clinical diagnosis of squamous epithelial lesions and tumors. (c) 2007 Optical Society of America.