Comparison between Xylazine-Tiletamine-Zolazepam and Fentanyl-Tiletamine- Zolazepam Anaesthetic Combinations on Plasma Oxidative Status in Sheep
Comparison between Xylazine-Tiletamine-Zolazepam and Fentanyl-Tiletamine- Zolazepam Anaesthetic Combinations on Plasma Oxidative Status in Sheep
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DOI：
10.2754/avb200776040573
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发表时间：
2007
影响因子：
0.6
通讯作者：
N. Aydilek
中科院分区：
文献类型：
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作者：
N. Aydilek
甲拉嗪-替乐胺-唑拉西泮与芬太尼-替乐胺-唑拉西泮两种麻醉组合对绵羊血浆氧化状态的影响。《兽医。中国生物医学工程学报，2007,26(6):573-578。确定麻醉药的不同作用是很重要的。全身麻醉的不良反应之一是外源性活性氧的来源。本研究比较了噻嗪-替莱胺-唑西泮（XTZ）和芬太尼-替莱胺-唑西泮（FTZ）联合用药对绵羊血浆氧化-抗氧化指标的影响。10只母羊在10天的间隔内接受两种不同的麻醉组合。XTZ组注射噻嗪和替乐胺唑西泮。FTZ组注射芬太尼和替乐胺唑西泮。分别于麻醉前、麻醉后30、60、120 min、24 h和3 d采集血样。两种麻醉方案均引起血浆丙二醛（MDA）浓度升高。XTZ组MDA浓度在60、120 min和24 h显著高于FTZ组。在30、60、120 min和24 h时，XTZ组的谷胱甘肽（GSH）浓度显著低于基线值，而FTZ组仅在120 min时降低。与FTZ组相比，XTZ组在60和120 min时GSH浓度显著降低。XTZ组β -胡萝卜素浓度在120 min和24 h时均下降，而FTZ组仅在120 min时下降。仅XTZ组的谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）活性在120 min和24 h时下降。各组间<s:1>胡萝卜素浓度、CAT活性和GSH-Px活性均无显著差异。综上所述，XTZ和FTZ麻醉方案均可诱导绵羊氧化应激。XTZ组合比FTZ组合对MDA和GSH浓度的影响更大。因此，FTZ麻醉组合被认为更适合用于绵羊麻醉，因为它对氧化/抗氧化平衡的影响较小。
Aydilek N.: Comparison between Xylazine-Tiletamine-Zolazepam and Fentanyl-TiletamineZolazepam Anaesthetic Combinations on Plasma Oxidative Status in Sheep. Acta Vet. Brno 2007, 76: 573-578. It is important to determine varying effects of anaesthetics agents. One of the adverse effects of general anaesthetics are the exogenous sources of reactive oxygen species. In this study, the effects of xylazine-tiletamine-zolazepam (XTZ) and fentanyl-tiletamine-zolazepam (FTZ) combinations on plasma oxidant-antioxidant indicators were compared in sheep. Ten ewes received two different anaesthetic combinations in a ten-day interval. XTZ group was injected with xylazine and tiletamine-zolazepam. FTZ group was injected with fentanyl and tiletamine-zolazepam. Blood samples were collected before and at the 30, 60, 120 min, 24 h and 3 days after anaesthesia. Both anaesthetic regimens caused an increase in malondialdehyde (MDA) concentrations in plasma. The MDA concentrations at 60, 120 min and 24 h in the XTZ group were significantly higher than in the FTZ group. Glutathione (GSH) concentration at 30, 60, 120 min and 24 h was significantly lower than baseline values in XTZ group, while there was only a decrease at 120 min in the FTZ group. GSH concentrations in the XTZ group were significantly lower at 60 and 120 min compared with the FTZ group. Beta carotene concentration was decreased at 120 min and 24 h in the XTZ group, while it decreased only at 120 min in the FTZ group. Glutathione peroxidase (GSH-Px) and catalase (CAT) activities decreased at 120 min and 24 h only in the XTZ group. There were no significant differences in -carotene concentration, activities CAT and GSH-Px activities between groups. In conclusion, both XTZ and FTZ anaesthetic regimens induced oxidative stress in sheep. XTZ combination has more detrimental effect than FTZ combinations on particularly MDA and GSH concentrations. Therefore, FTZ anaesthetic combination is considered to be more suitable for sheep anaesthesia, due to less deteriorating effects on oxidant/antioxidant balance.