Effect of tauroursodeoxycholic acid on bile acid‐induced apoptosis in primary human hepatocytes
Effect of tauroursodeoxycholic acid on bile acid‐induced apoptosis in primary human hepatocytes
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DOI：
10.1046/j.1365-2362.2000.00615.x
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发表时间：
2000-03
影响因子：
5.5
通讯作者：
C. Benz;S. Angermüller;G. Otto;P. Sauer;W. Stremmel;A. Stiehl
中科院分区：
文献类型：
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作者：
C. Benz;S. Angermüller;G. Otto;P. Sauer;W. Stremmel;A. Stiehl
The accumulation of endogenous bile acids contributes to hepatocellular damage during cholestatic liver disease. To evaluate the potential role of apoptotic cell death due to increased concentrations of bile acids, primary human hepatocytes were treated with hydrophobic and hydrophilic bile acids. Because the Fas receptor–ligand system may mediate apoptosis in human liver cells, the effect of toxic bile acids on hepatocellular Fas receptor expression was evaluated.
