Effects of acetate on luminal acidification processes in the S3 segment of the rabbit proximal tubule.
Effects of acetate on luminal acidification processes in the S3 segment of the rabbit proximal tubule.
复制标题
醋酸盐对兔近曲小管 S3 段管腔酸化过程的影响。
DOI：
10.1152/ajprenal.1989.257.4.f586
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Boron,WF
中科院分区：
文献类型：
--
作者：
Geibel,J;Giebisch,G;Boron,WF
我们确定，在名义上没有HCO-3的情况下，醋酸（Ac-）在兔近端小管S3段加倍管腔酸化。这种刺激有两个组成部分，一个依赖于Na+和腔内Ac-，另一个独立于Na+但依赖于基底外侧Ac-。在25 mM HCO-3存在下，Ac-不刺激酸的分泌（即HCO-3的再吸收），而实际上是抑制酸的分泌。双侧Ac-抑制率为35%，基底侧Ac-抑制率为15%。在HCO-3存在和不存在的情况下，Ac-的作用都是可逆的，并且在低至1mm的浓度下都存在。我们得出结论，醋酸盐（即单羧酸盐）在HCO-3存在和不存在的情况下对腔内酸化过程都有显著影响。
We determined that, in the nominal absence of HCO-3, acetate (Ac-) doubles luminal acidification in the S3 segment of the rabbit proximal tubule. This stimulation had two components, one that was dependent on Na+ and luminal Ac- and a second that was independent of Na+ but dependent on basolateral Ac-. In the presence of 25 mM HCO-3, Ac- did not stimulate acid secretion (i.e., HCO-3 reabsorption), but actually inhibited it. The inhibition was 35% with bilateral Ac- and 15% with basolateral Ac-. The effects of Ac- were reversible both in the absence and presence of HCO-3, and are present at concentrations as low as 1 mM. We conclude that acetate (i.e., monocarboxylates) has a significant effect on luminal acidification processes both in the presence and absence of HCO-3.