Pulmonary effects of the cocaine pyrolysis product, methylecgonidine, in guinea pigs.
Pulmonary effects of the cocaine pyrolysis product, methylecgonidine, in guinea pigs.
复制标题
可卡因热解产物甲基爱康定对豚鼠的肺部影响。
DOI：
10.1016/0024-3205(94)00410-t
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发表时间：
1995
期刊：
影响因子：
6.1
通讯作者：
Wood,RW
中科院分区：
文献类型：
--
作者：
Chen,LC;Graefe,JF;Shojaie,J;Willetts,J;Wood,RW
在豚鼠中评估可卡因热解产物甲基爱贡定（MEG;脱水爱贡定甲酯）的肺效应。在暴露于含有MEG游离碱（13 ± 1 mg/L空气）、雾化MEG富马酸盐（3%和12%磷酸盐缓冲盐水）或雾化氯化乙酰胆碱（0.2%和0.4%磷酸盐缓冲盐水）的冷凝气雾剂的豚鼠中，测量了在支气管收缩期间降低的比气道传导率（SGaw）。SGaw降低至24.0 ± 4.2%（平均值± 2 S.E.M.）在吸入MEG游离碱的豚鼠中观察到基线水平。0.4%乙酰胆碱给药后，观察到降低至基线的28.4 ± 4.5%。在暴露于3%富马酸MEG的豚鼠中未测量到SGaw变化，但暴露于12%富马酸MEG后，SGaw降低至基线的69.3 ± 5.3%。MEG游离碱对肺造成碱性挑战，3% MEG富马酸盐为中性（pH ≥ 7.4），12% MEG富马酸盐为酸性（pH ≥ 4.3）;因此，MEG游离碱和12% MEG富马酸盐可能因直接肺刺激作用而引起反射性支气管收缩。这些结果表明，在裂解裂解过程中产生的MEG游离碱可能在裂解吸烟者中观察到的支气管收缩中发挥作用。
The pulmonary effects of the cocaine pyrolysis product, methylecgonidine (MEG; anhydroecgonine methyl ester), were assessed in guinea pigs. Specific airway conductance (SGaw), which decreases during bronchoconstriction, was measured in guinea pigs exposed to atmospheres containing a condensation aerosol of MEG free base (13 ± 1 mg/liter of air), nebulized MEG fumarate (3 and 12% in phosphate buffered saline) or nebulized acetylcholine chloride (0.2 and 0.4% in phosphate buffered saline). A decrease in SGaw to 24.0 ± 4.2% (mean ± 2 S.E.M.) of baseline levels was observed in guinea pigs breathing MEG free base. A decrease to 28.4 + 4.5% of baseline was observed following administration of 0.4% acetylcholine. No change in SGaw was measured in guinea pigs exposed to 3% MEG fumarate but SGaw was reduced to 69.3 ± 5.3% of baseline after exposure to 12% MEG fumarate. MEG free base poses an alkaline challenge to the lung, 3% MEG fumarate is neutral (pH ≈ 7.4) and 12% MEG fumarate is acidic (pH ≈ 4.3); thus, MEG free-base and 12% MEG fumarate might provoke a reflex bronchoconstriction due to direct pulmonary irritant effects. These results suggest that MEG free base produced during crack pyrolysis may play a role in bronchoconstriction observed in crack smokers.