Physical inactivity as a risk factor for primary and secondary coronary events in Göteborg, Sweden.
Physical inactivity as a risk factor for primary and secondary coronary events in Göteborg, Sweden.
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在瑞典哥德堡，缺乏身体活动是原发性和继发性冠状动脉事件的危险因素。
DOI：
10.1093/eurheartj/9.suppl_l.8
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发表时间：
1988
影响因子：
39.3
通讯作者：
L. Wilhelmsen
中科院分区：
文献类型：
--
作者：
S. Johansson;A. Rosengren;A. Tsipogianni;G. Ulvenstam;I. Wiklund;L. Wilhelmsen
在哥德堡一级预防研究中随机抽取了7495名中年男性和1273名首次心肌梗死的健全男性患者（1968- 1984年期间在同一城市的梗死登记处登记），通过问卷调查研究了他们在工作和休闲时间的体力活动。冠状动脉危险因素和社会经济因素的数据被记录在人口样本中的危险因素和已知的躯体预后预测因素的梗死组的数据。在随机样本中，发现休闲时间体力活动与平均舒张压、总胆固醇、体重指数、吸烟、社会经济地位和精神压力之间存在反向和分级关联。在大约12年的随访中，在单变量分析中，休闲时间而不是工作时间的低体力活动与冠状动脉死亡和非致命性梗死的风险增加相关。不活动受试者的总冠状动脉事件发生率（9.4%）是体育活动受试者（4.2%）的两倍。在多因素Logistic回归分析中控制了主要冠心病危险因素、职业类别、糖尿病、冠心病家族史和精神压力后，休闲时间体力活动与总冠状动脉事件之间的相关性消失。在首次梗死前12个月的工作和休闲时间的体力活动与梗死后的长期预后无关。由于躯体限制、工作相关因素和情绪不稳定，被评估为需要额外康复的梗死患者恢复工作较晚，随访期间死亡率和非致死性复发率高于不需要额外康复的患者。在这项研究中，缺乏体力活动不是原发性和继发性冠状动脉事件的危险因素。休闲时间体力活动和冠状动脉危险因素之间的关联的反向表明，增加体力活动改变了危险因素的有利方向。
Physical activity at work and during leisure time were studied by using a questionnaire in a random sample of 7495 middle-aged men from the Primary Prevention Study in Göteborg and in 1273 able-bodied male patients with a first myocardial infarction, registered in the Infarction Register in the same city over the period 1968-84. Data on coronary risk factors and socio-economic factors were recorded in the population sample as were data on risk factors and known somatic predictors for prognosis in the infarction group. An inverse and graded association was found between leisure time physical activity and mean diastolic blood pressure, total cholesterol, body mass index, tobacco smoking, socio-economic status and mental stress in the random sample. During the approximate 12-year follow-up, low physical activity during leisure time, but not at work, was associated with an increased risk of coronary deaths and non-fatal infarctions in univariate analysis. Inactive subjects had twice the incidence of total coronary events (9.4%) as physically active contemporaries (4.2%). After controlling for major coronary risk factors, occupational class, diabetes, family history of coronary heart disease and mental stress in a multivariate logistic regression analysis, the association between leisure time physical activity and total coronary events disappeared. Physical activity at work and during leisure time estimated for the 12-month period preceding the first infarction was not associated with long-term prognosis after infarction. Infarction patients assessed to be in need of additional rehabilitation due to somatic restrictions, work-related factors and emotional instability, resumed work later and had a higher mortality and non-fatal recurrence rate during follow-up than patients not considered to require additional rehabilitation. Physical inactivity was not a risk factor for primary and secondary coronary events in this study. The inverse direction of the association between leisure time physical activity and coronary risk factors suggests that increased physical activity alters the risk factor profile in a favourable direction.