Techniques for noninvasive molecular imaging of atherosclerotic plaque
Techniques for noninvasive molecular imaging of atherosclerotic plaque
复制标题
动脉粥样硬化斑块的无创分子成像技术
DOI：
10.1038/nrcardio.2014.80-c2
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发表时间：
2015
影响因子：
49.6
通讯作者：
J. Rudd
中科院分区：
文献类型：
--
作者：
J. Tarkin;J. Rudd
We thank Federico Caobelli and Frank M. Bengel for their Correspondence (In vivo evaluation of atherosclerotic plaques and culprit lesions using noninvasive techniques. Nat. Rev. Cardiol. doi:10.1038/ nrcardio.2014.80-c1)1 on our Review (PET imaging of inflammation in atherosclerosis. Nat. Rev. Cardiol. 11, 443–457; 2014)2 and welcome their comments. We agree that advances in molecular imaging of plaques have the potential to change how we think about the management of athero sclerosis, and help to direct treatment towards patients at the highest risk of future clinical events. Several noninvasive molecular imaging platforms have been used to study atherosclerosis, each with varied success and limitations.3 Caobelli and Bengel highlight some exciting results from plaque imaging studies using SPECT, and the benefits of cadmium–zinc–telluride (CZT) SPECT over conventional SPECT with sodium iodide scintillation cameras. The remit of our Review was specific to PET imaging; other noninvasive molecular imaging modalities used in athero sclerosis research include MRI with ultrasmall super paramagnetic iron oxide, ultrasonography with microbubble antibody ligands, multidetector CT with iodine-based or gold-based nanoparticles, and SPECT with 99mTc-labellin g or 111In-labelling. Notably, in vivo leukocyte tracking using 99mTc-labelled autologous peripheral blood monocytes with serial SPECT imaging seems to correlate with vascular inflammation determined by 18F-FDG PET uptake, as well as disease severity assessed using MRI.4 99mTc-labelled folate is another potentially useful imaging marker for plaque, which has been examined using ex vivo microSPECT imaging of human carotid arteries.5 At present, these molecular imaging techniques are experimental and, therefore, none is widely accessible for use in patients with atherosclerosis. With any nuclear imaging method, whether SPECT or PET, inherent technical REPLY
影响因子：
4.9
作者：
Maddahi J;Packard RR
通讯作者：
Packard RR