The use of tetrodotoxin for the characterization of drug-enhanced dopamine release in conscious rats studied by brain dialysis
The use of tetrodotoxin for the characterization of drug-enhanced dopamine release in conscious rats studied by brain dialysis
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使用河豚毒素表征通过脑透析研究的清醒大鼠中药物增强的多巴胺释放
DOI：
10.1007/bf00169306
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. B. Vries
中科院分区：
文献类型：
--
作者：
B. Westerink;J. Tuntler;G. Damsma;Hans Rollema;J. B. Vries
研究了TTX(纹状体和伏隔核脑透析时注入)对多巴胺、3，4-二羟基苯乙酸和高香草酸释放的影响。此外，还研究了不同药物治疗引起的多巴胺释放增加是否对TTX输注敏感。研究了以下药物：氟哌啶醇、苯丙胺、氟哌啶醇与GBR 12909合用、吗啡和MPP+。除吗啡外，在纹状体进行了透析，在伏核进行了研究。TTX的注射显示了三种不同类型的药物促进清醒大鼠的多巴胺释放。首先，动作电位依赖的多巴胺释放(胞吐作用)，在未经治疗的动物以及氟哌啶醇、氟哌啶醇+GBR 12909和吗啡治疗的动物中观察到。第二，在苯丙胺的情况下，建立了动作电位独立释放(载体介导)。第三，在MPP+输注过程中观察到动作电位非依赖性的DA释放，可能是由神经毒性反应引起的。
SummaryThe effect of TTX (infused during brain dialysis of the striatum and nucleus accumbens) on the in vivo release of dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid, was investigated. In addition it was studied whether the increase in the release of dopamine, induced by various pharmacological treatments, was sensitive to TTX infusion. The following drugs were studied: haloperidol, amphetamine, haloperidol co-administered with GBR 12909, morphine and MPP+. Dialysis was carried out in the striatum, except for morphine, which was studied in the nucleus accumbens. The infusion of TTX revealed three different types of pharmacologically enhanced dopamine release in conscious rats. First, action potential dependent dopamine release (exocytosis), which was observed in untreated animals as well as in animals treated with haloperidol, haloperidol + GBR 12909, and morphine. Second, action potential independent release (carrier-mediated) was established in the case of amphetamine. Third, action potential independent DA release, probably caused by neurotoxic reactions was observed during MPP+ infusion.
脑线粒体能量驱动的 N-甲基-4-苯基吡啶摄取介导 MPTP 的神经毒性。
影响因子：
6.1
作者：
Ramsay,RR;Dadgar,J;Trevor,A;Singer,TP
通讯作者：
Singer,TP