Type 2 diabetes mellitus: The impact on colorectal adenoma risk in women
Type 2 diabetes mellitus: The impact on colorectal adenoma risk in women
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DOI：
10.1111/j.1572-0241.2006.00651.x
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发表时间：
2006-08-01
影响因子：
9.8
通讯作者：
Early, Dayna S.
中科院分区：
文献类型：
--
作者：
Elwing, Jill E.;Gao, Feng;Early, Dayna S.
结论：结直肠癌（CRC）的风险增加与2型糖尿病有关。尽管有几项研究将胰岛素抵抗与CRC风险增加联系起来，但关于糖尿病女性结直肠腺瘤风险的数据有限。我们假设，糖尿病妇女将增加结直肠腺瘤的发病率相对于一组nondiabetic women.METHODS：结直肠腺瘤率测定在100雌激素阴性的妇女与2型糖尿病，并与500非糖尿病，雌激素阴性对照。腺瘤定义为任何腺瘤或晚期腺瘤（绒毛状或管状绒毛状特征，大小> 1 cm或高度异型增生）。一个多变量模型包括年龄、种族、糖尿病、高血压、高胆固醇血症、体重指数和非甾体类抗炎药状态，用于确定糖尿病对结直肠腺瘤发病率的独立影响。与非糖尿病患者相比，糖尿病患者的任何腺瘤（37%对24%，p = 0.009）和晚期腺瘤（14%对6%，p = 0.009）的发生率更高。与355名非肥胖受试者相比，245名肥胖受试者的任何腺瘤发生率更高（32% vs 22%，p = 0.001）。肥胖糖尿病患者与非肥胖、非糖尿病患者相比，任何腺瘤的发生率更高（42%对23%，p
OBJECTIVES: Increased risk for colorectal cancer (CRC) has been associated with type 2 diabetes. Despite several studies linking insulin resistance to increased CRC risk, there are limited data on colorectal adenoma risk in diabetic women. We hypothesized that diabetic women would have increased rates of colorectal adenomas relative to a group of nondiabetic women.METHODS: Colorectal adenoma rates were determined in 100 estrogen-negative women with type 2 diabetes mellitus and compared with 500 nondiabetic, estrogen-negative controls. Adenomas were defined as any adenoma or advanced adenoma (villous or tubulovillous features, size > 1 cm or high-grade dysplasia). A multivariate model including age, race, diabetes, hypertension, hypercholesterolemia, body mass index, and nonsteroidal anti-inflammatory drug status was used to determine the independent effects of diabetes on colorectal adenoma incidence.RESULTS: Diabetics as compared with nondiabetics had greater rates of any adenoma (37% vs 24%, p = 0.009) and advanced adenomas (14% vs 6%, p = 0.009). Two hundred forty-five obese subjects compared with 355 nonobese subjects had a higher rate of any adenoma (32% vs 22%, p = 0.001.). Obese diabetics compared with nonobese, nondiabetics had greater rates of any adenoma (42% vs 23%, p