Seizures with Antidepressants: An In Vitro Technique to Assess Relative Risk
Seizures with Antidepressants: An In Vitro Technique to Assess Relative Risk
复制标题
抗抑郁药癫痫发作：评估相对风险的体外技术
作者：
D. Luchins;A. Oliver;R. Wyatt
摘要：通过检查各种抗抑郁药对灌注豚鼠海马切片中尖峰活动的作用，研究了各种抗抑郁药在以治疗剂量使用时诱发癫痫发作的相对潜力。在研究的浓度范围内，丙咪嗪、阿米替林、去甲替林、马普替林和地昔帕明倾向于按效果降序增加尖峰活性。多塞平和诺米芬辛在较低浓度下增加尖峰活性，但在较高浓度下降低尖峰活性。普罗替林和曲米帕明随着浓度的增加而降低尖峰活性，而米安色林和维洛沙嗪在任何浓度下几乎没有影响。根据以前的临床和实验室报告讨论了这些发现，并提出了这些发现的临床意义。最后，将抗抑郁药的结果与之前使用精神安定药观察到的结果进行比较。根据这一比较和对临床报告的回顾，精神安定药比抗抑郁药具有更大致癫痫潜力的假设受到质疑。
Summary: The relative potential of various antidepressants to induce seizures while being used at therapeutic doses was studied by examining their action on spike activity in perfused guinea pig hippocampal slices. Within the range of concentration studied, imipramine, amitriptyline, nortriptyline, maprotiline, and desipramine tended to increase spike activity in a descending order of effect. Doxepin and nomifensine increased spike activity at lower concentrations, but reduced it at higher concentrations. Protriptyline and trimipramine reduced spike activity with increasing concentrations, whereas mianserin and viloxazine had little effect at any concentration. These findings are discussed in light of previous clinical and laboratory reports, and the clinical implications of these findings are presented. Finally, results with the antidepressants are compared with those previously observed with neuroleptics. On the basis of this comparison and a review of clinical reports, the assumption that neuroleptics have greater epileptogenic potential than antidepressants is questioned.