Angiotensin-converting enzyme gene polymorphisms and obesity: an examination of three black populations.
Angiotensin-converting enzyme gene polymorphisms and obesity: an examination of three black populations.
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血管紧张素转换酶基因多态性和肥胖：对三个黑人群体的检查。
DOI：
10.1038/oby.2005.94
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Cooper,Richard
中科院分区：
文献类型：
--
作者：
Kramer,Holly;Wu,Xiaodong;Kan,Donghui;Luke,Amy;Zhu,Xiaofeng;Adeyemo,Adebowale;McKenzie,Colin;Cooper,Richard
我们研究了肥胖与13血管紧张素转换酶（ACE）基因多态性之间的关系，包括16号内含子中Alu元素的存在(I)或缺失(D) （I/D多态性），并使用从尼日利亚伊巴丹黑人高血压社区调查参与者中收集的数据进行了单倍型分析；牙买加西班牙城；在每个研究群体中检测了脸基因多态性和单倍型从杂合亲本到受影响后代的传播畸变。为了估计单倍型，多态性根据其在acegene上的位置分为三组。在3个种群中，noace1基因多态性持续从父母传给肥胖后代。然而，在美国和尼日利亚人群中，位于启动子区域的单倍型ACE1‐ACE5 TACAT从父母过度传递给肥胖的后代。在牙买加人中，没有单倍型从父母过度传递给肥胖的后代。总之，我们注意到在两个独立的黑人群体中，一个特定的基因启动子区域单倍型从父母过度传递给肥胖的后代。这些数据表明，乙酰胆酸基因多态性可能影响体重增加的发展。
We examined the association between obesity and 13angiotensin‐converting enzyme(ACE) gene polymorphisms, including the presence (I) or absence (D) of an Alu element in intron 16 (I/Dpolymorphism), and performed haplotype analysis using data collected from participants of a community survey of hypertension among blacks living in Ibadan, Nigeria; Spanish Town, Jamaica; and Chicago, IL. Transmission distortion ofACEgene polymorphisms and haplotypes from heterozygous parents to affected offspring was examined in each study population. To estimate haplotypes, polymorphisms were divided into three groups based on their position on theACEgene. NoACEgene polymorphism was consistently overtransmitted from parents to obese offspring among the three populations. However, the haplotype ACE1‐ACE5 TACAT, located in the promoter region, was significantly overtransmitted from parents to obese offspring in both the U.S. and Nigerian populations. No haplotype was significantly overtransmitted from parents to obese offspring among the Jamaicans. In conclusion, we noted the overtransmission of a particularACEgene promoter region haplotype from parents to obese offspring in two separate black populations. These data suggest thatACEgene polymorphisms may influence the development of weight gain.