INHIBITION OF MAMMALIAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE BY STEROIDS
INHIBITION OF MAMMALIAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE BY STEROIDS
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DOI：
10.1073/pnas.46.4.447
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发表时间：
1960-01-01
影响因子：
11.1
通讯作者：
BANKS, J
中科院分区：
文献类型：
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作者：
MARKS, PA;BANKS, J
脱氢异雄酮、孕烯醇酮和某些相关类固醇，浓度为 1 x 10-6 [图片] 或更低时，会抑制哺乳动物葡萄糖-6-磷酸脱氢酶活性。这些类固醇不会抑制 6-磷酸葡萄糖酸或异柠檬酸脱氢酶或菠菜或酵母葡萄糖-6-磷酸脱氢酶。多种其他类固醇，包括雌激素、睾酮、皮质类固醇和黄体酮，在浓度高达 4 x 10~5 时对葡萄糖-6-磷酸脱氢酶几乎没有影响[图片]。
Dehydroisoandrosterone, pregnenolone, and certain related steroids, at concentrations of 1 x 10-6 [image] or less, inhibit mammalian glucose-6-phosphate dehydrogenase activity. These steroids do not inhibit 6-phosphogluconic or isocitric dehydrogenases or spinach or yeast glucose-6-phosphate dehydrogenase. A variety of other steroids including estrogens, testosterone, corticosteroids, and progesterone had little effect on glucose-6-phosphate dehydrogenase in concentrations as high as 4 x 10~5 [image].