Significant reduction in bacterial shedding and improvement in milk production in dairy farms after the use of a new inactivated paratuberculosis vaccine in a field trial.
Significant reduction in bacterial shedding and improvement in milk production in dairy farms after the use of a new inactivated paratuberculosis vaccine in a field trial.
复制标题
DOI：
10.1186/1756-0500-2-233
复制
发表时间：
2009-11-22
影响因子：
1.8
通讯作者：
Garrido, Joseba M
中科院分区：
文献类型：
--
作者：
Juste, Ramon A;Alonso-Hearn, Marta;Garrido, Joseba M
背景：副结核病疫苗接种在一些地区已使用数十年，但效果尚未广泛推广。鸟分枝杆菌新亚种。在四个农场中研究了副结核病 (MAP) 灭活疫苗及其对粪便排泄和产奶量的影响，而另外两个农场则作为对照提交给测试和扑杀计划。 结果：在干预开始的两年（5 个牛群）和四年（1 个牛群）后对粪便检测（n = 1829）和挤奶记录（n = 2413）进行了分析。四个接种疫苗农场中的三个农场的脱落率降低了 100%，接种疫苗的动物总数降低了 68%，两个对照农场降低了 46%。接种疫苗的农场的 MAP 棚总量减少了 77%，对照农场减少了 94%。疫苗接种后总体产奶量增加了 3.9%，而未接种疫苗的农场在干预后产量没有显着差异。结论：通过疫苗接种以及检测和扑杀都可以快速减少 MAP 脱落。然而，疫苗接种似乎是一种更便宜、更可持续的策略，因为它需要一次干预，而且还与牛奶产量的增加有关。
BACKGROUND: Paratuberculosis vaccination has been in use in some regions for many decades, but results have not been widely spread. A new Mycobacterium avium subsp. paratuberculosis (MAP) killed vaccine was studied in relationship with its effects on fecal shedding and milk production in four farms while other two were kept as controls submitted to a test and cull scheme.FINDINGS: Fecal detection (n = 1829) and milking records (n = 2413) have been analyzed after two (5 herds) and four (1 herd) years of the beginning of the intervention. Shedder prevalence was reduced by 100% in three of the four vaccinated farms, 68% in the total of vaccinated animals and 46% in the two control farms. Total amount of MAP shed was reduced 77% in the vaccinated farms and 94% in the control farms. Overall milk production increased up to 3.9% after vaccination, while there was no significant difference in production after intervention in the non-vaccinated farms.CONCLUSION: MAP shedding reduction can be quickly accomplished both by vaccination and by testing and culling. However, vaccination appears to be a less expensive and more sustainable strategy since it required one single intervention and was also associated with an increase in milk production.