The potential role of O-GlcNAc modification in cancer epigenetics.
The potential role of O-GlcNAc modification in cancer epigenetics.
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DOI：
10.2478/s11658-014-0204-6
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发表时间：
2014-09
影响因子：
8.3
通讯作者：
Krześlak A
中科院分区：
文献类型：
--
作者：
Forma E;Jóźwiak P;Bryś M;Krześlak A
毫无疑问，癌症不仅是一种遗传性疾病，而且还可能由于表观遗传异常而发生。饮食和环境因素可以改变表观遗传调控的范围。最近的研究结果表明，o - glcn酰化（涉及在蛋白质的丝氨酸或苏氨酸残基上添加n -乙酰氨基葡萄糖）可能在响应细胞代谢状态的表观基因组调节中发挥关键作用。有两种酶负责环o - glcn酰化：O-GlcNAc转移酶（OGT），它催化GlcNAc片段添加到靶蛋白上；以及O-GlcNAcase (OGA)，它可以从蛋白质中去除糖。O-GlcNAc循环酶的异常表达，特别是OGT，在所有研究的人类癌症中都被发现。OGT通过与HCF-1、TET、mSin3A、HDAC、BAP1等多种表观遗传因子相互作用和修饰，将癌细胞的细胞代谢状态与表观遗传状态联系起来。来自动物模型系统的越来越多的证据也表明，OGT在多梳依赖性基因活性抑制中起着重要作用。此外，o - glcna酰化可能是组蛋白编码的一部分：O-GlcNAc残基存在于所有核心组蛋白上。
There is no doubt that cancer is not only a genetic disease but that it can also occur due to epigenetic abnormalities. Diet and environmental factors can alter the scope of epigenetic regulation. The results of recent studies suggest that O-GlcNAcylation, which involves the addition of N-acetylglucosamine on the serine or threonine residues of proteins, may play a key role in the regulation of the epigenome in response to the metabolic status of the cell. Two enzymes are responsible for cyclic O-GlcNAcylation: O-GlcNAc transferase (OGT), which catalyzes the addition of the GlcNAc moiety to target proteins; and O-GlcNAcase (OGA), which removes the sugar moiety from proteins. Aberrant expression of O-GlcNAc cycling enzymes, especially OGT, has been found in all studied human cancers. OGT can link the cellular metabolic state and the epigenetic status of cancer cells by interacting with and modifying many epigenetic factors, such as HCF-1, TET, mSin3A, HDAC, and BAP1. A growing body of evidence from animal model systems also suggests an important role for OGT in polycomb-dependent repression of genes activity. Moreover, O-GlcNAcylation may be a part of the histone code: O-GlcNAc residues are found on all core histones.
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影响因子：
11.2
作者：
Chernikova SB;Razorenova OV;Higgins JP;Sishc BJ;Nicolau M;Dorth JA;Chernikova DA;Kwok S;Brooks JD;Bailey SM;Game JC;Brown JM
通讯作者：
Brown JM
DOI：
10.1073/pnas.1013822108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Daou, Salima;Mashtalir, Nazar;Affar, El Bachir
通讯作者：
Affar, El Bachir
DOI：
10.1016/j.bbrc.2010.11.138
发表时间：
2011-01-07
影响因子：
3.1
作者：
Gao, Zhen;Xu, C. Wilson
通讯作者：
Xu, C. Wilson
影响因子：
37.3
作者：
Ducasse M;Brown MA
通讯作者：
Brown MA
影响因子：
3.4
作者：
Champattanachai, Voraratt;Netsirisawan, Pukkavadee;Svasti, Jisnuson
通讯作者：
Svasti, Jisnuson