Zein-based composites in biomedical applications
Zein-based composites in biomedical applications
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DOI：
10.1002/jbm.a.36040
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发表时间：
2017-06-01
影响因子：
4.9
通讯作者：
Boccaccini, Aldo R.
中科院分区：
文献类型：
--
作者：
Demir, Merve;Ramos-Rivera, Laura;Boccaccini, Aldo R.
在过去的十年中，相当多的研究工作致力于基于玉米醇溶蛋白的生物材料用于组织工程和其他生物医学应用。对玉米醇溶蛋白基聚合物的关注主要归因于其生物相容性和生物降解性。然而，由于这些聚合物的机械性能相对较低，许多无机化合物（例如，羟基磷灰石、磷酸钙、生物活性玻璃、天然粘土）与玉米醇溶蛋白结合以产生复合材料，试图提高玉米醇溶蛋白的机械性能。无机相也对玉米醇溶蛋白基质的亲水性产生积极影响，诱导细胞附着、铺展和增殖的合适环境。本文综述了玉米醇溶蛋白和玉米醇溶蛋白基复合材料的研究进展，重点介绍了玉米醇溶蛋白与常用无机填料的结合在组织工程和药物释放方面的应用。综述了玉米醇溶蛋白基复合材料制备技术的最新进展，并重点介绍了该领域的主要应用领域和未来发展。(c)2017 Wiley Periodicals，Inc.
Considerable research efforts have been devoted to zein-based biomaterials for tissue engineering and other biomedical applications over the past decade. The attention given to zein-based polymers is primarily attributed to their biocompatibility and biodegradability. However, due to the relatively low mechanical properties of these polymers, numerous inorganic compounds (e.g., hydroxyapatite, calcium phosphate, bioactive glasses, natural clays) have been considered in combination with zein to create composite materials in an attempt to enhance zein mechanical properties. Inorganic phases also positively impact on the hydrophilic properties of zein matrices inducing a suitable environment for cell attachment, spreading, and proliferation. This review covers available literature on zein and zein-based composite materials, with focus on the combination of zein with commonly used inorganic fillers for tissue engineering and drug delivery applications. An overview of the most recent advances in fabrication techniques for zein-based composites is presented and key applications areas and future developments in the field are highlighted. (c) 2017 Wiley Periodicals, Inc.