Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis.
Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis.
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在跨诊断方法中绘制快感缺失特异性功能障碍：ALE 荟萃分析
DOI：
10.1007/s11682-015-9457-6
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发表时间：
2016-09
影响因子：
3.2
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Zhang B;Lin P;Shi H;Öngür D;Auerbach RP;Wang X;Yao S;Wang X
快感缺乏是神经精神障碍的一个突出症状，在重性抑郁症（MDD）和精神分裂症（SZ）中最为明显。新出现的证据表明，在MDD和SZ之间的快感缺失的神经基质的重叠，这支持了transdiagnosis方法。因此，我们使用激活似然估计（ALE）的功能磁共振成像研究在MDD和SZ的荟萃分析，以检查快感缺乏的三个子域的神经基础：完成性快感缺乏，预期快感缺乏和情绪处理。后来使用专门针对MDD或SZ的ALE分析将特定的快感缺失相关神经生物学损伤与潜在的疾病一般损伤分离。ALE结果显示，完全性快感缺失与腹侧基底神经节区域的激活减少有关，而预期性快感缺失与除腹侧纹状体（包括背侧前扣带回、额中回和额内侧回）之外的额-纹状体网络中的更多底物有关。MDD和SZ患者在预期性和完成性快感缺乏方面表现出相似的神经生物学损伤，但在情绪体验任务方面存在差异，这可能也涉及情感/情绪一般处理。这些结果支持快感缺乏的特点是奖励处理的改变，并依赖于额叶-纹状体脑回路。跨诊断的方法是一种很有前途的方式，揭示整体神经生物学框架，有助于快感缺失，并可能有助于改善有针对性的治疗策略。本文的在线版本（doi：10.1007/s11682-015-9457-6）包含补充材料，可供授权用户使用。
Anhedonia is a prominent symptom in neuropsychiatric disorders, most markedly in major depressive disorder (MDD) and schizophrenia (SZ). Emerging evidence indicates an overlap in the neural substrates of anhedonia between MDD and SZ, which supported a transdiagnostic approach. Therefore, we used activation likelihood estimation (ALE) meta-analysis of functional magnetic resonance imaging studies in MDD and SZ to examine the neural bases of three subdomains of anhedonia: consummatory anhedonia, anticipatory anhedonia and emotional processing. ALE analysis focused specifically on MDD or SZ was used later to dissociate specific anhedonia-related neurobiological impairments from potential disease general impairments. ALE results revealed that consummatory anhedonia was associated with decreased activation in ventral basal ganglia areas, while anticipatory anhedonia was associated with more substrates in frontal-striatal networks except the ventral striatum, which included the dorsal anterior cingulate, middle frontal gyrus and medial frontal gyrus. MDD and SZ patients showed similar neurobiological impairments in anticipatory and consummatory anhedonia, but differences in the emotional experience task, which may also involve affective/mood general processing. These results support that anhedonia is characterized by alterations in reward processing and relies on frontal-striatal brain circuitry. The transdiagnostic approach is a promising way to reveal the overall neurobiological framework that contributes to anhedonia and could help to improve targeted treatment strategies. The online version of this article (doi:10.1007/s11682-015-9457-6) contains supplementary material, which is available to authorized users.