Cognition in patients with newly diagnosed brain metastasis: profiles and implications
Cognition in patients with newly diagnosed brain metastasis: profiles and implications
复制标题
DOI：
10.1007/s11060-014-1543-x
复制
发表时间：
2014-10-01
影响因子：
3.9
通讯作者：
Triebel, Kristen L.
中科院分区：
文献类型：
--
作者：
Gerstenecker, Adam;Nabors, Louis B.;Triebel, Kristen L.
认知障碍是脑转移患者的常见症状，大多数仍能进行基本自我护理活动的患者普遍存在明显的认知功能障碍。在当前的研究中，使用一系列标准化神经心理学测试对 32 名脑转移患者和 32 名人口统计学匹配的对照组的神经认知表现进行了检查，目的是全面检查新诊断的脑转移患者的认知功能。所有患者的认知能力在开始脑转移治疗后 1 周内进行评估。结果表明，与健康对照组相比，言语记忆、注意力、执行功能和语言均受到损害。还检查了与适当规范组相关的绩效。总体而言，认知缺陷很普遍，记忆力是最常见的障碍。鉴于这组患者存在认知功能障碍，功能损伤基本上很轻微，这些结果对治疗脑转移患者的患者、护理人员和医疗保健提供者具有重要意义。
Cognitive impairment is a common symptom in patients with brain metastasis, and significant cognitive dysfunction is prevalent in a majority of patients who are still able to engage in basic self-care activities. In the current study, the neurocognitive performance of 32 patients with brain metastasis and 32 demographically-matched controls was examined using a battery of standardized neuropsychological tests, with the goal of comprehensively examining the cognitive functioning of newly diagnosed brain metastasis patients. The cognition of all patients was assessed within 1 week of beginning treatment for brain metastasis. Results indicated impairments in verbal memory, attention, executive functioning, and language in relation to healthy controls. Performance in relation to appropriate normative groups was also examined. Overall, cognitive deficits were prevalent and memory was the most common impairment. Given that cognitive dysfunction was present in this cohort of patients with largely minimal functional impairment, these results have implications for patients, caregivers and health care providers treating patients with brain metastasis.