SYMPATHOADRENAL SYSTEM AND REGULATION OF THERMOGENESIS
SYMPATHOADRENAL SYSTEM AND REGULATION OF THERMOGENESIS
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DOI：
10.1152/ajpendo.1984.247.2.e181
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
YOUNG, JB
中科院分区：
文献类型：
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作者：
LANDSBERG, L;SAVILLE, ME;YOUNG, JB
交感神经系统（SNS）在哺乳动物对冷暴露和饮食摄入的产热反应的调节中起着关键作用。儿茶酚胺刺激的产热是由β -肾上腺素能受体介导的。在大鼠中，棕色脂肪组织是应对寒冷（非寒战产热）和饮食（饮食诱导产热）时代谢产热的主要部位。大鼠肩胛间棕色脂肪组织的去甲肾上腺素周转率的测量表明，在寒冷暴露和过度喂养的反应中，交感神经活动增加。在成人中，棕色脂肪组织在生理上的重要作用尚未确定，但不能排除。SNS活动的饮食变化似乎与代谢率的变化相关，至少部分相关，而代谢率的变化与饮食摄入量的变化相关。
The sympathetic nervous system (SNS) plays a critical role in the regulation of mammalian thermogenic responses to cold exposure and dietary intake. Catecholamine-stimulated thermogenesis is mediated by the beta-adrenergic receptor. In the rat brown adipose tissue is the major site of metabolic heat production in response to both cold (nonshivering thermogenesis) and diet (diet-induced thermogenesis). Measurements of norepinephrine turnover rate in interscapular brown adipose tissue of the rat demonstrate increased sympathetic activity in response to both cold exposure and overfeeding. In adult humans, a physiologically significant role for brown adipose tissue has not been established but cannot be excluded. It appears likely that dietary changes in SNS activity are related, at least in part, to the changes in metabolic rate that occur in association with changes in dietary intake.