PHOSPHORYLATION OF THE DROSOPHILA-ADHERENS JUNCTION PROTEIN ARMADILLO - ROLES FOR WINGLESS SIGNAL AND ZESTE-WHITE 3-KINASE
PHOSPHORYLATION OF THE DROSOPHILA-ADHERENS JUNCTION PROTEIN ARMADILLO - ROLES FOR WINGLESS SIGNAL AND ZESTE-WHITE 3-KINASE
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DOI：
10.1006/dbio.1994.1336
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发表时间：
1994-12-01
影响因子：
2.7
通讯作者：
CASEY, M
中科院分区：
文献类型：
--
作者：
PEIFER, M;PAI, LM;CASEY, M
果蝇体节极性基因产物Armadillo提供了两个看似独立的过程之间的联系，即无翅细胞间信号对体节模式的调节和细胞-细胞粘附连接的功能。犰狳最初被鉴定是因为它的片段极性表型，但随后发现它是脊椎动物粘附连接蛋白β-连环蛋白的同源物。我们研究了犰狳的翻译后修饰的性质及其在调节犰狳功能中的可能作用。犰狳是一种磷蛋白。它的磷酸化水平在胚胎发育过程中和组织之间都有变化。磷酸化发生在丝氨酸或苏氨酸和酪氨酸残基上。最后，Wingless信号负调控Armadillo磷酸化，而片段极性基因产物Zesande-white 3，一种丝氨酸/苏氨酸蛋白激酶，促进Armadillo磷酸化。我们讨论了这些结果对Wingless/Wnt-1信号传导和粘附连接功能调节的影响。(C)1994年出版社出版。
The Drosophila segment polarity gene product Armadillo provides a link between two seemingly separate processes, regulation of segmental pattern by the Wingless intercellular signal and the function of cell-cell adherens junctions. armadillo was originally identified because of its segment polarity phenotype but subsequently was found to be the homolog of the vertebrate adherens junction protein beta-catenin. We examined the nature of the post-translational modification of Armadillo and its possible role in regulating Armadillo function. Armadillo is a phosphoprotein. Its level of phosphorylation varies both during embryonic development and from tissue to tissue. Phosphorylation occurs on both serine or threonine and tyrosine residues. Finally, Wingless signal negatively regulates Armadillo phosphorylation, while the segment polarity gene product Zesande-white 3, a serine/threonine protein kinase, promotes Armadillo phosphorylation. We discuss the implications of these results for regulation of Wingless/Wnt-1 signaling and adherens junction function. (C) 1994 Academic Press, Inc.