Polyoxovanadate-iodobodipy supramolecular assemblies: new agents for high efficiency cancer photochemotherapy
Polyoxovanadate-iodobodipy supramolecular assemblies: new agents for high efficiency cancer photochemotherapy
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DOI：
10.1039/c9cc09944a
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发表时间：
2020-03-07
影响因子：
4.9
通讯作者：
Ruhlmann, Laurent
中科院分区：
文献类型：
--
作者：
Gu, Yaqi;Li, Qi;Ruhlmann, Laurent
首次通过阴离子六钒酸盐和十钒酸盐分别与阳离子iodoBodipy自组装，合成了两种新型多钒酸盐-iodoBodipy超分子组装体，命名为（2 I-BDP-C-6）（2）V-6和（2 I-BDP-C-6）（3）V-10，用于光化学治疗。确定了阴阳离子对协同光化学疗法的机制。特别是，（2 I-BDP-C-6）（3）V-10可通过协同化疗以及光动力疗法有效地杀死肺癌细胞（HepG 2）。
Two novel polyoxovanadate-iodoBodipy supramolecular assemblies, named as (2I-BDP-C-6)(2)V-6 and (2I-BDP-C-6)(3)V-10, were first synthesized by the self-assembly of anionic hexavanadate and decavanadate with cationic iodoBodipy for photochemotherapy, respectively. The mechanisms for synergistic photochemotherapy of the anion-cation pairs were determined. In particular, (2I-BDP-C-6)(3)V-10 can effectively kill lung cancer cells (HepG2) by synergetic chemotherapy as well as photodynamic therapy.