Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease
Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease
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DOI：
10.1002/ana.92
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发表时间：
2001-04-01
影响因子：
11.2
通讯作者：
Rossor, MN
中科院分区：
文献类型：
--
作者：
Chan, D;Fox, NC;Rossor, MN
对 30 名受试者进行体积磁共振成像分析，以量化语义痴呆和阿尔茨海默氏病的整体和颞叶萎缩。研究分为三组，每组 10 名受试者：语义痴呆患者、阿尔茨海默病患者和对照受试者。测量的颞叶结构为杏仁核、海马、内嗅皮质、海马旁回、梭状回以及颞上回、中回和下回。语义性痴呆和阿尔茨海默病组在整体萎缩测量上没有显着差异。在语义性痴呆中，存在不对称的颞叶萎缩，左侧损伤更严重。颞叶萎缩分布呈前后梯度，前方萎缩较明显。所有左前颞叶结构均受到语义性痴呆的影响，其中内嗅皮层、杏仁核、颞中回和颞下回以及梭状回受损最严重。还存在不对称的、主要是前海马萎缩。在阿尔茨海默病中，内嗅皮层、海马体和杏仁核对称萎缩，但没有证据表明颞叶或海马体萎缩的分布存在前后梯度。这些数据表明，语义性痴呆和阿尔茨海默病中颞叶萎缩的分布存在显着差异。此外，语义痴呆的萎缩模式表明，语义记忆受到前颞叶结构的促进，其中颞中回和颞下回可能发挥关键作用。
Volumetric magnetic resonance imaging analyses of 30 subjects were undertaken to quantify the global and temporal lobe atrophy in semantic dementia and Alzheimer's disease. Three groups of 10 subjects were studied: semantic dementia patients, Alzheimer's disease patients, and control subjects. The temporal lobe structures measured were the amygdala, hippocampus, entorhinal cortex, parahippocampal gyrus, fusiform gyrus, and superior, middle, and inferior temporal gyri. Semantic dementia and Alzheimer's disease groups did not differ significantly on global atrophy measures. In semantic dementia, there was asymmetrical temporal lobe atrophy, with greater left-sided damage. There was an anteroposterior gradient in the distribution of temporal lobe atrophy, with more marked atrophy anteriorly. All left anterior temporal lobe structures were affected in semantic dementia, with the entorhinal cortex, amygdala, middle and inferior temporal gyri, and fusiform gyrus the most severely damaged. Asymmetrical, predominantly anterior hippocampal atrophy was also present. In Alzheimer's disease, there was symmetrical atrophy of the entorhinal cortex, hippocampus, and amygdala, with no evidence of an anteroposterior gradient in the distribution of temporal Lobe or hippocampal atrophy. These data demonstrate that there is a marked difference in the distribution of temporal lobe atrophy in semantic dementia and Alzheimer's disease. In addition, the pattern of atrophy in semantic dementia suggests that semantic memory is subserved by anterior temporal lobe structures, within which the middle and inferior temporal gyri may play a key role.