Greater cortical gray matter density in lithium-treated patients with bipolar disorder
Greater cortical gray matter density in lithium-treated patients with bipolar disorder
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DOI：
10.1016/j.biopsych.2006.10.027
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发表时间：
2007-07-01
影响因子：
10.6
通讯作者：
Soares, Jair C.
中科院分区：
文献类型：
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作者：
Bearden, Carrie E.;Thompson, Paul M.;Soares, Jair C.
背景：双相情感障碍的神经生物学基础还不清楚。以前的神经影像学结果一直不一致;然而，三维（3-D）计算图像分析的新方法可能比标准体积测量更好地表征神经解剖学变化。我们使用高分辨率磁共振成像和皮质模式匹配方法来绘制28名双相情感障碍成年人的灰质差异，其中70%接受锂治疗（平均年龄= 36.1 ± 10.5; 13例女性受试者），28例健康对照受试者（平均年龄= 35.9 ± 8.5; 11例女性受试者）。灰质密度（GMD）进行了详细的空间分析，通过测量本地比例的灰质在数以千计的同源cortical locations.Results：灰质密度显着更大的双相患者相对于对照组在弥漫性皮层区域。最大的差异被发现在双侧扣带皮层和边缘皮层，大脑区域的注意力，动机和情绪调节的关键。次要感兴趣区（1301）分析表明，锂治疗的双相情感障碍患者（n = 20）的右前扣带回GMD显著高于未服用锂的患者（n = 8）。这些脑图与之前的体素一致基于双相情感障碍患者前边缘网络部分GMD更大的形态学报告，并建议锂作为一种这些神经解剖学差异的可能病因。
Background: The neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures.Methods: We used high-resolution magnetic resonance imaging and cortical pattern matching methods to map gray matter differences in 28 adults with bipolar disorder, 70% of whom were lithium-treated (mean age = 36.1 +/- 10.5; 13 female subject), and 28 healthy control subjects (mean age = 35.9 +/- 8.5; 11 female subjects). Detailed spatial analyses of gray matter density (GMD) were conducted by measuring local proportions of gray matter at thousands of homologous cortical locations.Results: Gray matter density was significantly greater in bipolar patients relative to control subjects in diffuse cortical regions. Greatest differences were found in bilateral cingulate and paralimbic cortices, brain regions critical for attentional, motivational, and emotional modulation. Secondary region of interest (1301) analyses indicated significantly greater GMD in the right anterior cingulate among lithium-treated bipolar patients (n = 20) relative to those not taking lithium (n = 8).Conclusions: These brain maps are consistent with previous voxel-based morphometry reports of greater GMD in portions of the anterior limbic network in bipolar patients and suggest neurotrophic effects of lithium as a possible etiology of these neuroanatomic differences.