Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an in vitro study of rat cardiomyocytes
Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an in vitro study of rat cardiomyocytes
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DOI：
10.1111/j.1471-0528.2004.00166.x
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发表时间：
2004-08-01
影响因子：
5.8
通讯作者：
Williamson, C
中科院分区：
文献类型：
--
作者：
Gorelik, J;Shevchuk, A;Williamson, C
产科胆汁淤积与宫内死亡有关。在产科胆汁淤积症中，初级胆汁酸与牛磺酸的结合比甘氨酸更常见，而糖结合物在正常妊娠中占主导地位。使用大鼠心肌细胞的体外模型，我们比较了牛磺和糖结合胆酸盐对心肌细胞节律，收缩幅度和网络完整性的影响。我们证明了牛磺胆酸盐对所有这些参数有更显著的影响，并且糖缀合物的影响是完全可逆的，而牛磺缀合物的影响则不是。产科胆汁淤积症中牛磺结合胆汁酸的比例增加可能是导致宫内死亡的病因。
Obstetric cholestasis is associated with intrauterine death. In obstetric cholestasis, primary bile acids are more commonly conjugated with taurine than glycine, while glycoconjugates predominate in normal pregnancy. Using an in vitro model of rat cardiomyocytes, we compared the effect of tauro- and glycoconjugated cholate on cardiomyocyte rhythm, contraction amplitude and network integrity. We demonstrated that taurocholate had a more marked effect on all of these parameters, and the effects of the glycoconjugates were fully reversible while those of tauroconjugates were not. The increased proportion of tauroconjugated bile acids in obstetric cholestasis may contribute to the aetiology of the intrauterine death associated with the condition.